Oleanane-type saponins from Lysimachia laxa Baudo and their antibacterial activities.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2024-09-20 DOI:10.1093/bbb/zbae095

Nguyen Thi Luyen, Nguyen Tien Dat, Do Hoang Giang, Nguyen Thi Kim Thuy, Bui Huu Tai, Phan Thi Thanh Huong, Le Thi Phuong Quynh, Duong Thi Thuy, SeonJu Park, Nguyen Xuan Nhiem

引用次数: 0

Abstract

Seven new oleanane-type triterpene saponins, lysimaponins A-G, were isolated from aerial parts of Lysimachia laxa Baudo. Their chemical structures have been elucidated by analysis of spectroscopic and chemical methods. All compounds were evaluated for their antibacterial effects against Microcystis aeruginosa, Vibrio parahaemolyticus, V. harveyi, V. vulinificus, V. cholerae, and V. alginolyticus. All compounds showed potent antibacterial activities against the cyanobacteria M. aeruginosa with IC50 values ranging from 14.4 ± 1.2 to 35.3 ± 2.2 µg/mL. Compounds 1, 2, 4-7 inhibited V. parahaemolyticus with MIC values ranging from 64 to 256 µg/mL. The results suggested that saponins from L. laxa could be potential anti-cyanobacteria agents.

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来自 Lysimachia laxa Baudo 的齐墩果烷型皂甙及其抗菌活性。

从 Lysimachia laxa Baudo 的气生部分分离出了七种新的齐墩果烷型三萜皂甙，即 Lysimaponins A-G。通过光谱和化学方法的分析，阐明了它们的化学结构。评估了所有化合物对铜绿微囊藻、副溶血性弧菌、哈维氏弧菌、弧菌、霍乱弧菌和藻溶弧菌的抗菌效果。所有化合物对蓝藻铜绿微囊藻都有很强的抗菌活性，其 IC50 值从 14.4 ± 1.2 到 35.3 ± 2.2 µg/mL 不等。化合物 1、2、4-7 可抑制副溶血弧菌，其 MIC 值介于 64 至 256 µg/mL 之间。结果表明，腊肠皂苷可能是潜在的抗蓝藻菌药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).