Combination of a Topical Anti-Inflammatory Drug and a Moisturizer, Both with a Lamellar Structure Containing Synthetic Pseudo-Ceramides, for the Treatment of Patients with Mild-to-Moderate Atopic Dermatitis

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-03 DOI:10.2147/ccid.s467934

Keita Okoshi, Shotaro Ito, Megumi Matsuoka, Yoshinori Kinugasa, Eri Shimizu, Kosei Tanaka, Joji Okada, Takahiro Nishizaka, Azumi Nagasawa, Tsuyoshi Seki, Makoto Iijima, Masatoshi Abe, Osamu Nemoto

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引用次数: 0

Abstract

Purpose: Atopic dermatitis is characterized by chronic inflammation and dryness accompanied by severe itching. The combined use of moisturizers and topical anti-inflammatory drugs is essential for alleviating atopic dermatitis. We have developed a topical anti-inflammatory drug with a steroid and a moisturizer with heparinoid, both in lamellar structure-based formulations containing synthetic pseudo-ceramides. Here, assessed the efficacy of this combination in the treatment of atopic dermatitis.
Methods: We included 22 patients with mild to moderate atopic dermatitis and subjected them to a seven-week treatment with the test formulations, followed by a four-week post-treatment period.
Results: Clinical findings and the quality of life of participants remarkably improved after one week of treatment. Furthermore, skin hydration and transepidermal water loss considerably improved at weeks one and three, respectively. The Cer [NP]/[NS] ratio, an indicator of epidermal turnover, substantially increased during the treatment period and remained elevated even thereafter. The improvement in stratum corneum function was distinctive in participants with lower barrier function.
Conclusion: These findings indicated that the combined use of the anti-inflammatory drug and moisturizer, both in lamellar structure-based formulations, is effective in treating atopic dermatitis in patients with fragile barrier function.

Keywords: base formulations, lamellar structure, steroid, heparinoid, barrier function, TEWL

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将一种外用消炎药和一种保湿霜（二者均具有含有合成假橘皮酰胺的层状结构）结合使用，治疗轻度至中度特应性皮炎患者

目的：特应性皮炎的特点是慢性炎症和干燥，并伴有剧烈瘙痒。要缓解特应性皮炎，必须同时使用保湿剂和外用消炎药。我们开发了一种含类固醇的外用消炎药和一种含肝素的保湿剂，这两种药物都是基于片状结构的配方，含有合成的伪神经酰胺。在此，我们对这一组合治疗特应性皮炎的疗效进行了评估：我们纳入了 22 名轻度至中度特应性皮炎患者，让他们接受为期七周的试验配方治疗，然后进行为期四周的治疗后观察：结果：治疗一周后，患者的临床症状和生活质量明显改善。此外，在第一周和第三周，皮肤水合作用和经表皮失水情况也分别得到了显著改善。作为表皮新陈代谢指标的铈[NP]/[NS]比值在治疗期间大幅上升，甚至在治疗结束后仍保持在较高水平。角质层功能的改善在屏障功能较低的参与者中尤为明显：这些研究结果表明，联合使用抗炎药物和保湿剂（均为片状结构制剂）可有效治疗屏障功能脆弱的特应性皮炎患者。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.