Voltammetric Determination of Levofloxacin in Meat and Milk Using a Sensor Based on Electroreduced Graphene Oxide and Functionalized Fullerene

IF 1 4区化学 Q4 CHEMISTRY, ANALYTICAL

Journal of Analytical Chemistry Pub Date : 2024-06-21 DOI:10.1134/s1061934824700060

I. A. Abramov, S. I. Gainanova, L. R. Zagitova, V. N. Maistrenko

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Abstract

Antibacterial drugs have become an integral part of the food industry and agriculture in the present-day world. The presence of even trace amounts of antibiotics in foods of animal origin can lead to the development of allergic reactions and direct toxic effects in a human body. In this regard, it is necessary to create sensitive and selective procedures for determining antibacterial drugs in order to prevent their excessive consumption. In this work, a glassy carbon voltammetric sensor based on layer-by-layer deposited electroreduced graphene oxide and fullerene functionalized with S-N,N'-bis(1-phenylethyl)malonamide is proposed for the determination of levofloxacin (Lev, S-(-)-ofloxacin) by differential pulse voltammetry. The calibration graph is linear in two ranges, 1.0 × 10^–6–6.0 × 10^–5 M and 6.0 × 10^–5–5.0 × 10^–4 M Lev, with sensitivity coefficients of 107 and 58.0 μA/mM, respectively. The limit of detection and limit of quantification are 1.8 × 10^–7 and 6.04 × 10^–7 M, respectively. The selectivity of the sensor to Lev relative to some fluoroquinolone antibiotics: ciprofloxacin, lomefloxacin, and enrofloxacin, was assessed. The sensor was used to determine Lev in meat and milk using differential pulse voltammetry.

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使用基于电还原石墨烯氧化物和功能化富勒烯的传感器以伏安法测定肉类和牛奶中的左氧氟沙星

摘要抗菌药物已成为当今世界食品工业和农业不可或缺的一部分。动物源性食品中即使含有微量的抗生素，也会导致过敏反应的发生，并对人体产生直接的毒性作用。因此，有必要建立灵敏且有选择性的抗菌药物测定程序，以防止抗菌药物的过度消费。本研究提出了一种基于逐层沉积电还原氧化石墨烯和富勒烯的玻璃碳伏安传感器，该传感器由 S-N,N'-双(1-苯基乙基)丙二酰胺功能化，通过差分脉冲伏安法测定左氧氟沙星（Lev，S-(-)-ofloxacin）。在 1.0 × 10-6-6.0 × 10-5 M 和 6.0 × 10-5-5.0 × 10-4 M Lev 两个范围内，校准图呈线性关系，灵敏度系数分别为 107 和 58.0 μA/mM。检测限和定量限分别为 1.8 × 10-7 M 和 6.04 × 10-7 M。评估了该传感器相对于一些氟喹诺酮类抗生素（环丙沙星、洛美沙星和恩诺沙星）对 Lev 的选择性。该传感器被用于使用差分脉冲伏安法测定肉类和牛奶中的 Lev 含量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Analytical Chemistry 化学-分析化学

CiteScore

2.10

自引率

9.10%

发文量

146

审稿时长

13 months

期刊介绍： The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.