The emerging role of brain neuroinflammatory responses in Alzheimer’s disease

IF 4.1 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2024-07-03 DOI:10.3389/fnagi.2024.1391517

Mandana Amelimojarad, Melika Amelimojarad, Xiaonan Cui

引用次数: 0

Abstract

As the most common cause of dementia, Alzheimer’s disease (AD) is characterized by neurodegeneration and synaptic loss with an increasing prevalence in the elderly. Increased inflammatory responses triggers brain cells to produce pro-inflammatory cytokines and accelerates the Aβ accumulation, tau protein hyper-phosphorylation leading to neurodegeneration. Therefore, in this paper, we discuss the current understanding of how inflammation affects brain activity to induce AD pathology, the inflammatory biomarkers and possible therapies that combat inflammation for AD.

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大脑神经炎症反应在阿尔茨海默病中的新作用

阿尔茨海默病（AD）是最常见的痴呆症，以神经变性和突触丧失为特征，在老年人中的发病率越来越高。炎症反应的增加会引发脑细胞产生促炎细胞因子，加速 Aβ 的积累和 tau 蛋白的过度磷酸化，从而导致神经退行性变。因此，在本文中，我们将讨论目前对炎症如何影响大脑活动以诱发 AD 病理学、炎症生物标志物以及抗炎治疗 AD 的可能疗法的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.