Ultra-fast setting rate of a new bioactive binder for bone repair

IF 2.4 3区化学 Q3 POLYMER SCIENCE

Iranian Polymer Journal Pub Date : 2024-06-23 DOI:10.1007/s13726-024-01354-1

Ning Gu, Qingxiao Liu, Qichao Liu, Ying Ren, Xiaodong Liu, Youyi Sun, Yang Cao

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Abstract

Polymer bone binder has attracted lots of attention due to its facile preparation, biodegradability, and so on. However, achieving strong adhesion, easy preparation, and fast setting rate for polymer bone binding is still a great challenge. So, here, a new polymer bone binder is developed and prepared to simultaneously improve setting rate and strength. The bone binder is composed of polyethyleneglycol, ethylhydroacrylate, chitosan, and SiO₂ nanoparticles. It exhibits good biocompatibility and large bonding strength (ca. 2.0 MPa). Furthermore, the bone binder shows an ultra-fast setting rate (ca. 100 s), which is far faster than that reported in previous works. The bone binder is further evaluated to bond chicken bone, which exhibits a high binding force of 2.0 kgf in a short setting time of only 5.0 min. The good biocompatibility and the large bonding strength of the present bone binder are attributed to the green and environmentally friendly composition (e.g., cyanoacrylate, chitosan, polyethyleneglycol and SiO₂ nanoparticles) and cross-linking network between chitosan and SiO₂ nanoparticles. The ultra-fast setting process is attributed to the rapid polymerization of cyanoacrylate and the physical interaction of SiO₂ nanoparticles with chitosan and polyethyleneglycol. The work provides a new method to design and prepare high-performance bone binders for use in bone fracture repair.

Graphical abstract

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用于骨修复的新型生物活性粘合剂的超快凝固率

聚合物骨粘合剂因其制备简便、可生物降解等优点而备受关注。然而，如何实现聚合物骨粘合剂的强粘合性、易制备性和快速凝固率仍然是一个巨大的挑战。因此，本文开发并制备了一种新型聚合物骨粘合剂，以同时提高固化率和强度。该骨粘合剂由聚乙二醇、氢丙烯酸乙酯、壳聚糖和纳米二氧化硅组成。它具有良好的生物相容性和较大的粘合强度（约 2.0 兆帕）。此外，这种骨粘合剂还具有超快的凝固速度（约 100 秒），远远快于之前的研究成果。我们进一步评估了骨粘合剂粘合鸡骨的效果，其粘合力高达 2.0 kgf，而固化时间仅为 5.0 分钟。本骨粘合剂具有良好的生物相容性和较大的粘合力，这归功于其绿色环保的成分（如氰基丙烯酸酯、壳聚糖、聚乙二醇和二氧化硅纳米粒子）以及壳聚糖和二氧化硅纳米粒子之间的交联网络。超快固化过程归功于氰基丙烯酸酯的快速聚合以及二氧化硅纳米粒子与壳聚糖和聚乙二醇的物理相互作用。这项研究为设计和制备用于骨折修复的高性能骨粘合剂提供了一种新方法。

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来源期刊

Iranian Polymer Journal 化学-高分子科学

CiteScore

4.90

自引率

9.70%

发文量

107

审稿时长

2.8 months

期刊介绍： Iranian Polymer Journal, a monthly peer-reviewed international journal, provides a continuous forum for the dissemination of the original research and latest advances made in science and technology of polymers, covering diverse areas of polymer synthesis, characterization, polymer physics, rubber, plastics and composites, processing and engineering, biopolymers, drug delivery systems and natural polymers to meet specific applications. Also contributions from nano-related fields are regarded especially important for its versatility in modern scientific development.