Development of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance
IF 9.6 1区 材料科学Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Xue-Yu Man, Ze-Wen Sun, Shan-He Li, Gang Xu, Wen-Juan Li, Zhen-Lei Zhang, Hong Liang, Feng Yang
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引用次数: 0
Abstract
Cisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal therapy (PTT) and immunotherapy. To this end, we obtained a platinum compound (C5) with significant cytotoxicity in the cisplatin-resistant SKOV-3 cells (SKOV-3/DDP), and then innovatively constructed photosensitizer (indocyanine green (ICG))-encapsulated HSA-C5 complex nanoparticles (ICG@HSA-C5 NPs). The ICG@HSA-C5 NPs exhibited excellent photothermal performances in vitro and in vivo. Importantly, the in vivo results revealed that HSA enhanced the antitumor effect of C5 and that the combination of chemotherapy and PTT could significantly inhibit cisplatin-resistant tumor growth and improved the targeting abilities of C5 and ICG, and reduced their side effects. We also confirmed that ICG@HSA-C5 NPs killed the SKOV-3/DDP cells via gasdermin E (GSDME)-mediated pyroptosis and pyroptosis-induced immune responses, thereby synergistically leading to the death of the SKOV-3/DDP cells.
期刊介绍:
Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.