A. A. Danilova, K. A. Gusev, D. N. Maimistov, E. V. Flisyuk
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引用次数: 0
Abstract
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant origin is confirmed by research data. The low bioavailability of flavonoids attributed to poor solubility and absorption in the gastrointestinal tract is a limiting factor in their use. Microand nano-milling technologies; complexation with surfactants, cyclodextrins, and chelating agents; and production of solid disperse systems are currently used to improve the physicochemical properties of polyphenolic compounds. Development of solid dispersion systems using hot melt extrusion is the most promising approach from the viewpoint of industrial implementation. The present review is devoted to consideration of current approaches to the use of hot extrusion of polyphenolic compounds to improve their pharmacokinetic and technological properties.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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