High gain transimpedance amplification for wireless glucose monitoring in a wearable health sensor system

Abstract

This paper presents the development of a wireless data acquisition system for a wearable health sensor designed to measure glucose levels, pulse rate, and body temperature. The method emphasizes non-invasive and continuous monitoring to provide timely healthcare interventions. The designed system prioritizes wearability, flexibility, compactness, and low power consumption for user comfort and convenience. A transimpedance amplifier is designed to increase the glucose sensor signal with optimal gain and bandwidth, utilizing modeling tools for accurate signal processing. Filters, amplifiers, analog-to-digital converters, and a microcontroller for data processing and wireless transmission were used to create an integrated multi-input readout circuit for all three sensors. The work aims to develop a small and efficient circuit consuming less than 100 mW and occupying less than 6 cm². This research extensively covers the design and optimization of a transimpedance amplifier, the development of an integrated multi-input readout circuit, and the incorporation of low-power Bluetooth data transfer for a wearable health sensor system. The biosensor’s 10 uA signal range was effectively amplified to a voltage level that is readable, guaranteeing a minimum gain of 10,000 and converting it from current to voltage for measurement. An important milestone was achieved by integrating the communication of the amplified signal, heart rate, and temperature characteristics to the host application using Bluetooth. The complete system has been efficiently contained within a compact 6 cm² footprint.