Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection.

IF 12.8 1区工程技术 Q1 ENGINEERING, BIOMEDICAL

Annual Review of Biomedical Engineering Pub Date : 2024-07-01 DOI:10.1146/annurev-bioeng-110122-014306

Allen B Tu, Gaddam Krishna, Kevin R Smith, Jamal S Lewis

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引用次数: 0

Abstract

Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that are currently incurable, drastically decrease patient quality of life, and consume considerable health care resources. Underlying each of these diseases is a dysregulated immune system that results in the mounting of an inflammatory response against self or an innocuous antigen. As a consequence, afflicted patients are required to adhere to lifelong regimens of multiple immunomodulatory drugs to control disease and reclaim agency. Unfortunately, current immunomodulatory drugs are associated with a myriad of side effects and adverse events, such as increased risk of cancer and increased risk of serious infection, which negatively impacts patient adherence rates and quality of life. The field of immunoengineering is a new discipline that aims to harness endogenous biological pathways to thwart disease and minimize side effects using novel biomaterial-based strategies. We highlight and discuss polymeric micro/nanoparticles with inherent immunomodulatory properties that are currently under investigation in biomaterial-based therapies for treatment of autoimmunity, allergy, and transplant rejection.

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利用免疫调节聚合物治疗自身免疫、过敏和移植排斥反应。

自身免疫、过敏和移植排斥是一系列慢性疾病，这些疾病目前无法治愈，大大降低了患者的生活质量，并消耗了大量的医疗资源。这些疾病的根本原因都是免疫系统失调，导致对自身或无害抗原产生炎症反应。因此，患者需要终生服用多种免疫调节药物来控制疾病和恢复机体功能。遗憾的是，目前的免疫调节药物存在大量副作用和不良反应，如癌症风险增加、严重感染风险增加等，对患者的依从率和生活质量造成了负面影响。免疫工程领域是一门新学科，旨在利用基于生物材料的新策略，利用内源性生物途径来挫败疾病并最大限度地减少副作用。我们重点介绍并讨论了具有固有免疫调节特性的聚合物微/纳米颗粒，这些微/纳米颗粒目前正在研究用于治疗自身免疫、过敏和移植排斥反应的生物材料疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Biomedical Engineering 工程技术-工程：生物医学

CiteScore

18.80

自引率

0.00%

发文量

期刊介绍： Since 1999, the Annual Review of Biomedical Engineering has been capturing major advancements in the expansive realm of biomedical engineering. Encompassing biomechanics, biomaterials, computational genomics and proteomics, tissue engineering, biomonitoring, healthcare engineering, drug delivery, bioelectrical engineering, biochemical engineering, and biomedical imaging, the journal remains a vital resource. The current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.