Fungemia due to opportunistic fungi in patients with cancer

IF 1.5 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia Pub Date : 2024-01-01 DOI:10.1016/j.riam.2024.01.001

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引用次数: 0

Abstract

Background

Fungemia due to uncommon fungi and secondary to multiple risk factors has become an emergent health problem, particularly in oncology patients.

Aims

This study shows the following data collected during an 11-year period in a tertiary care oncologic center from patients with fungemia: demographic data, clinical characteristics, and outcome.

Methods

A retrospective study was performed at Instituto Nacional de Cancerología, a 135-bed referral cancer center in Mexico City, from July 2012 to June 2023. All episodes of non-Candida fungemia were included.

Results

Sixteen cases with uncommon fungemia were found in the database, representing 0.3% from all the blood cultures positive during the study period, and 8.5% from all the fungi isolated. The most common pathogens identified in our series were Histoplasma capsulatum, Acremonium spp., Trichosporon asahii, and Saccharomyces cerevisiae. Eight patients had hematologic malignancies, and five had severe neutropenia. In eight cases fungemia was considered catheter-related, in four cases was classified as primary, and in the last four it was diagnosed as disseminated fungal diseases. Mortality at 30 days was 43.8%.

Conclusions

The improved diagnostic tools have led to a better diagnosis of uncommon fungal infections. More aggressive therapeutic approaches, particularly in patients with malignancies, would increase survival rates in these potentially fatal diseases.

查看原文本刊更多论文

癌症患者因机会性真菌引起的菌血症。

背景：由不常见真菌引起并继发于多种风险因素的真菌血症已成为一个紧迫的健康问题，尤其是在肿瘤患者中。目的：本研究显示了在一家三级肿瘤中心的11年间收集的真菌血症患者的以下数据：人口统计学数据、临床特征和结果：2012年7月至2023年6月，在墨西哥城一家拥有135张床位的癌症转诊中心--国立癌症研究所（Instituto Nacional de Cancerología）进行了一项回顾性研究。研究纳入了所有非念珠菌性真菌病病例：结果：数据库中发现了16例非典型真菌血症病例，占研究期间所有血液培养阳性病例的0.3%，占所有真菌分离病例的8.5%。在我们的系列研究中，最常见的病原体是荚膜组织胞浆菌（Histoplasma capsulatum）、Acremonium spp.、旭三孢子菌（Trichosporon asahii）和酿酒酵母菌（Saccharomyces cerevisiae）。八名患者患有血液系统恶性肿瘤，五名患者患有严重的中性粒细胞减少症。8例真菌血症被认为与导管有关，4例被归类为原发性，最后4例被诊断为播散性真菌病。30天后的死亡率为43.8%：结论：诊断工具的改进提高了对不常见真菌感染的诊断率。更积极的治疗方法，尤其是针对恶性肿瘤患者的治疗方法，将提高这些潜在致命疾病的存活率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.