Yuxin Wang, Chengcheng Wang, Ruiqi Zhong, Liang Wang, Lei Sun
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引用次数: 0
Abstract
DNA methylation is one of the earliest and most significant epigenetic mechanisms discovered. DNA methylation refers, in general, to the addition of a methyl group to a specific base in the DNA sequence under the catalysis of DNA methyltransferase, with S‑adenosine methionine as the methyl donor, via covalent bonding and chemical modifications. DNA methylation is an important factor in inducing cancer. There are different types of DNA methylation, and methylation at different sites plays different roles. It is well known that the progression of colorectal cancer (CRC) is affected by the methylation of key genes. The present review did not only discuss the potential relationship between DNA methylation and CRC but also discussed how DNA methylation affects the development of CRC by affecting key genes. Furthermore, the clinical significance of DNA methylation in CRC was highlighted, including that of the therapeutic targets and biomarkers of methylation; and the importance of DNA methylation inhibitors was discussed as a novel strategy for treatment of CRC. The present review did not only focus upon the latest research findings, but earlier reviews were also cited as references to older literature.
DNA 甲基化是最早发现的最重要的表观遗传机制之一。DNA 甲基化泛指在 DNA 甲基转移酶的催化下,以 S-腺苷蛋氨酸为甲基供体,通过共价键和化学修饰,在 DNA 序列中的特定碱基上添加一个甲基。DNA 甲基化是诱发癌症的一个重要因素。DNA 甲基化有不同的类型,不同位点的甲基化起着不同的作用。众所周知,结直肠癌(CRC)的进展受关键基因甲基化的影响。本综述不仅讨论了 DNA 甲基化与 CRC 之间的潜在关系,还讨论了 DNA 甲基化如何通过影响关键基因来影响 CRC 的发展。此外,本综述还强调了 DNA 甲基化在 CRC 中的临床意义,包括甲基化的治疗靶点和生物标志物;并讨论了 DNA 甲基化抑制剂作为治疗 CRC 的新策略的重要性。本综述不仅关注最新的研究成果,还引用了以前的综述作为旧文献的参考资料。
期刊介绍:
Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.