STIM1: A new player in nuclear dynamics? Lessons learnt from tubular aggregate myopathy

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2024-06-24 DOI:10.1016/j.ceca.2024.102926

Emanuela Pessolano , Zlata A. Sosic , Armando A. Genazzani

引用次数: 0

Abstract

Two recent papers have highlighted that STIM1, a key component of Store-operated Ca2+-entry, is able to translocate to the nucleus and participate in nuclear Ca²⁺-handling and in DNA repair. These finding opens new avenues on the role that this Ca²⁺-sensing protein may have in health and disease.

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STIM1：核动力学的新角色？从肾小管聚集性肌病中汲取的教训

最近的两篇论文强调，STIM1 是储存器操作的 Ca2+ 进入的关键成分，它能够转位到细胞核，并参与核 Ca2+ 处理和 DNA 修复。这些发现为研究这种 Ca2+ 传感蛋白在健康和疾病中可能发挥的作用开辟了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes