Fleagrass (Adenosma buchneroides Bonati) Acts as a Fungicide Against Candida albicans by Damaging Its Cell Wall.

IF 3.3 4区生物学 Q2 MICROBIOLOGY

Journal of Microbiology Pub Date : 2024-08-01 Epub Date: 2024-07-03 DOI:10.1007/s12275-024-00146-9

Youwei Wu, Hongxia Zhang, Hongjie Chen, Zhizhi Du, Qin Li, Ruirui Wang

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Abstract

Fleagrass, a herb known for its pleasant aroma, is widely used as a mosquito repellent, antibacterial agent, and for treating colds, reducing swelling, and alleviating pain. The antifungal effects of the essential oils of fleagrass and carvacrol against Candida albicans were investigated by evaluating the growth and the mycelial and biofilm development of C. albicans. Transmission electron microscopy was used to evaluate the integrity of the cell membrane and cell wall of C. albicans. Fleagrass exhibited high fungicidal activity against C. albicans at concentrations of 0.5% v/v (via the Ras1/cAMP/PKA pathway). Furthermore, transmission electron microscopy revealed damage to the cell wall and membrane after treatment with the essential oil, which was further confirmed by the increased levels of β-1,3-glucan and chitin in the cell wall. This study showed that fleagrass exerts good fungicidal and hyphal growth inhibition activity against C. albicans by disrupting its cell wall, and thus, fleagrass may be a potential antifungal drug.

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跳蚤草（Adenosma buchneroides Bonati）通过破坏细胞壁对白色念珠菌起到杀菌作用。

飞蓬草是一种以芳香宜人而闻名的草本植物，被广泛用作驱蚊剂、抗菌剂以及治疗感冒、消肿和止痛。通过评估白念珠菌的生长、菌丝和生物膜的发育情况，研究了飞燕草精油和香芹酚对白念珠菌的抗真菌作用。透射电子显微镜用于评估白念珠菌细胞膜和细胞壁的完整性。在浓度为 0.5% v/v 时（通过 Ras1/cAMP/PKA 途径），马鞭草对白僵菌具有很高的杀菌活性。此外，透射电子显微镜显示精油处理后细胞壁和细胞膜受损，细胞壁中β-1,3-葡聚糖和几丁质含量的增加进一步证实了这一点。这项研究表明，飞蓬草通过破坏白僵菌的细胞壁，对其具有良好的杀菌和抑制菌丝生长的活性，因此，飞蓬草可能是一种潜在的抗真菌药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Microbiology 生物-微生物学

CiteScore

5.70

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Publishes papers that deal with research on microorganisms, including archaea, bacteria, yeasts, fungi, microalgae, protozoa, and simple eukaryotic microorganisms. Topics considered for publication include Microbial Systematics, Evolutionary Microbiology, Microbial Ecology, Environmental Microbiology, Microbial Genetics, Genomics, Molecular Biology, Microbial Physiology, Biochemistry, Microbial Pathogenesis, Host-Microbe Interaction, Systems Microbiology, Synthetic Microbiology, Bioinformatics and Virology. Manuscripts dealing with simple identification of microorganism(s), cloning of a known gene and its expression in a microbial host, and clinical statistics will not be considered for publication by JM.