Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-03 DOI:10.1080/10286020.2024.2371032

Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang

引用次数: 0

Abstract

Sesquilignans PD is a natural phenylpropanoid compound that was isolated from Zanthoxylum nitidum var. tomentosum. In this study, we assessed the antitumor effect of PD on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that PD markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, PD induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, PD increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of PD, which is mediated via increased ROS production and MAPK signaling activation.

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从 Zanthoxylum nitidum var. tomentosum 中提取的 Sesquilignans PD 可通过 ROS/MAPK 途径对肝癌细胞产生抗肿瘤作用。

Sesquilignans PD是从Zanthoxylum nitidum var.tomentosum中分离出来的一种天然苯丙类化合物。本研究评估了 PD 对 SK-Hep-1 和 HepG2 细胞的抗肿瘤作用及其分子机制。结果表明，PD 能显著抑制两种肝癌细胞的增殖和迁移。此外，PD 还能诱导肝癌细胞凋亡、自噬和活性氧（ROS）的产生。值得注意的是，PD 提高了肝癌细胞中 p-p38 MAPK 和 p-ERK1/2 的蛋白水平。这是首次报道通过增加 ROS 生成和激活 MAPK 信号来介导 PD 的抗癌作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.