Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-03 DOI:10.1080/10286020.2024.2368841

Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou

引用次数: 0

Abstract

Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.

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Atramacronoid A可通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞的泛凋亡样细胞死亡。

乳腺癌是最常见的恶性肿瘤，也是全球妇女死亡的主要原因。Atramacronoid A (AM-A) 是一种独特的天然倍半萜内酯，从白术根茎中分离出来。我们的研究表明，AM-A 能引发一种特殊形式的细胞死亡，类似于 PANoptosis 样细胞死亡。进一步的分析表明，AM-A诱导的PAN凋亡样细胞死亡与线粒体功能障碍介导的CASP-3/PARP-GSDMD-MLKL通路有关。这些结果表明，AM-A 有可能成为一种先导化合物，并为从天然产品中开发乳腺癌治疗药物提供了启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.