The role of revision sinus surgery in the initiation of dupilumab therapy: A real-world study of molecular and cellular features

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2024-07-03 DOI:10.1002/alr.23401

Abigail Gaffar MS, Abdul Rahman Alenezi MD, Kathleen M. Kelly MD, Heather M. Kulaga MS, Hsin-Tzu Keng MS, Amy Smith BA, Andrew P. Lane MD

引用次数: 0

Abstract

Key points

A persistent type 2 endotype signature exists in recalcitrant chronic rhinosinusitis with nasal polyps mucosa on dupilumab.
Revision sinus surgery immediately prior to dupilumab reduces long-term interleukin (IL)-4/IL-13 tissue mRNA.
Pre-dupilumab revision surgery is associated with reduced tissue eosinophils and GATA-3+ cells.

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鼻窦翻修手术在启动杜必鲁单抗治疗中的作用：分子和细胞特征的真实世界研究。

要点：在使用杜普鲁单抗的顽固性慢性鼻窦炎伴鼻息肉粘膜中存在持续的2型内型特征。在使用杜匹单抗前立即进行鼻窦翻修手术可减少白细胞介素 (IL)-4/IL-13 组织 mRNA 的长期存在。杜比卢单抗前的鼻窦翻修手术与组织嗜酸性粒细胞和 GATA-3+ 细胞减少有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.