Elevated Vitamin B12, Risk of Cancer, and Mortality: A Systematic Review.

IF 1.8 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2024-07-01 Epub Date: 2024-07-02 DOI:10.1080/07357907.2024.2366907

Sandra B Amado-Garzon, Luisana Molina-Pimienta, Andrea Vejarano-Pombo, Mariana Vélez-Bonilla, Jaime Moreno-Chaparro, Adriana Buitrago-Lopez

引用次数: 0

Abstract

Vitamin B12 (B12) is a molecule involved in several biological. Abnormally high levels are frequently found, but their causes can be multiple, and consequences have not been clearly elucidated. The objective of this review was to summarize the current evidence on the associations of elevated B12 and the development of cancer, and all-cause mortality in adults. Six references looking at mortality and seven looking at cancer risk were included. The evidence suggests an association between elevated B12 with a higher risk of cancer, with risk ratios ranging 1,88 to 5,9. There was less consistent evidence linking vitamin B12 and mortality.

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维生素 B12 升高、癌症风险和死亡率：系统回顾

维生素 B12（B12）是一种参与多种生物学活动的分子。维生素 B12 含量异常升高的现象屡见不鲜，但其原因可能是多方面的，其后果也尚未明确阐明。本综述旨在总结目前有关 B12 升高与癌症发病和成人全因死亡率之间关系的证据。其中包括六篇研究死亡率的参考文献和七篇研究癌症风险的参考文献。证据表明，B12 升高与癌症风险增加之间存在关联，风险比从 1.88 到 5.9 不等。而将维生素 B12 与死亡率联系起来的证据则不那么一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.