Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation

IF 12.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Léa Mammri, Paul T. Conduit
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引用次数: 0

Abstract

Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 14 γ-tubulin molecules. High-resolution cryo-EM structures of γ-TuRCs after nucleation show that these γ-TuRCs ‘close’ during nucleation to display only 13 γ-tubulin molecules for protofilament assembly.

Abstract Image

Abstract Image

γ-TuRC的低温电子显微镜结构揭示了微管成核的分子奥秘
细胞内的微管通常有 13 根原丝,但由多蛋白 y-TuRCs 复合物成核,这些复合物显示 14 个 γ-微管蛋白分子。成核后的γ-TuRCs的高分辨率低温电子显微镜结构显示,这些γ-TuRCs在成核过程中 "闭合",只显示13个γ-微管蛋白分子用于原丝组装。
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来源期刊
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS
CiteScore
22.00
自引率
1.80%
发文量
160
审稿时长
3-8 weeks
期刊介绍: Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.
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