The role of p130Cas/BCAR1 adaptor protein in the pathogenesis of cardiovascular diseases: A literature review

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

American heart journal plus : cardiology research and practice Pub Date : 2024-06-25 DOI:10.1016/j.ahjo.2024.100416

Ghazal Ghasempour Dabaghi , Mehrdad Rabiee Rad , Reza Amani-Beni , Bahar Darouei

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Abstract

Breast cancer anti-estrogen resistance-1 (p130Cas/BCAR1) is an adaptor protein of the cas(Cas) family. This protein regulates multiple complex pathways in different organs including bones, pancreas, and immune and cardiovascular systems. Although previous research well demonstrated the role of p130Cas/BCAR1 in different diseases especially cancers, a precise review study on the various effects of p130Cas/BCAR1 on cardiovascular diseases is missing. In this study, we reviewed mechanisms of action for p130Cas/BCAR1 impact, on cardiac embryonic development defects, hypertrophy and remodeling, pulmonary artery hypertension (PAH), and atherosclerosis. Also, we suggest feature direction for research and potential therapeutic implications. This study showed that p130Cas/BCAR1 can affect cardiovascular diseases in various mechanisms including actin stress fiber formation, attachment to focal adhesion kinase (FAK) and angiotensin II (Ang II), generation of reactive oxygen species (ROS), and growth factor signaling through amplifying receptor tyrosine kinase (RTKs).

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p130Cas/BCAR1 适应蛋白在心血管疾病发病机制中的作用：文献综述

乳腺癌抗雌激素-1（p130Cas/BCAR1）是 cas（Cas）家族的一种适配蛋白。该蛋白调节不同器官中的多种复杂通路，包括骨骼、胰腺、免疫和心血管系统。尽管之前的研究充分证明了 p130Cas/BCAR1 在不同疾病尤其是癌症中的作用，但目前还没有关于 p130Cas/BCAR1 对心血管疾病的各种影响的精确综述研究。在本研究中，我们回顾了 p130Cas/BCAR1 对心脏胚胎发育缺陷、肥大和重塑、肺动脉高压（PAH）和动脉粥样硬化的影响机制。同时，我们还提出了特色研究方向和潜在的治疗意义。这项研究表明，p130Cas/BCAR1 可通过多种机制影响心血管疾病，包括肌动蛋白应力纤维的形成、与病灶粘附激酶（FAK）和血管紧张素 II（Ang II）的粘附、活性氧（ROS）的生成以及通过放大受体酪氨酸激酶（RTKs）的生长因子信号转导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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