Kidney transplantation from a systemic lupus erythematosus donor and 1-year follow-up: A case report

IF 1.6 4区 医学 Q4 IMMUNOLOGY
Dawei Zhou , Junto Leung , Yan Xiong , Shaojun Ye , Wei Zhou , Qifa Ye , Yanfeng Wang
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引用次数: 0

Abstract

Systemic lupus erythematosus (SLE) is usually regarded as a relative contraindication for deceased kidney donation. The pathological variations because of the changes in the immune environment after kidney transplantation (KT) are unclear, and the recovery of renal function is poorly understood. We present a case of KT from a deceased donor with SLE who was followed-up for one year. Although SLE-related hemangioma developed during the perioperative period, it was cured after interventional treatment. A pre-planned biopsy was performed one year after KT, and it was found that most of the pathological changes and immunofluorescent markers of lupus had resolved. Renal function was stable, and urinary protein and occult blood levels reduced one year after KT.

系统性红斑狼疮捐献者的肾移植手术及 1 年随访:病例报告。
系统性红斑狼疮(SLE)通常被视为肾脏捐献的相对禁忌症。肾移植(KT)后免疫环境的变化导致的病理变化尚不清楚,肾功能的恢复情况也不甚了解。我们介绍了一例随访一年的系统性红斑狼疮肾移植病例。虽然在围手术期出现了系统性红斑狼疮相关的血管瘤,但经过介入治疗后已经痊愈。KT 一年后进行了预先计划的活组织检查,发现狼疮的大部分病理变化和免疫荧光标记物已经消失。KT 一年后,肾功能稳定,尿蛋白和潜血水平降低。
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来源期刊
Transplant immunology
Transplant immunology 医学-免疫学
CiteScore
2.10
自引率
13.30%
发文量
198
审稿时长
48 days
期刊介绍: Transplant Immunology will publish up-to-date information on all aspects of the broad field it encompasses. The journal will be directed at (basic) scientists, tissue typers, transplant physicians and surgeons, and research and data on all immunological aspects of organ-, tissue- and (haematopoietic) stem cell transplantation are of potential interest to the readers of Transplant Immunology. Original papers, Review articles and Hypotheses will be considered for publication and submitted manuscripts will be rapidly peer-reviewed and published. They will be judged on the basis of scientific merit, originality, timeliness and quality.
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