Low-Grade Adenosquamous Carcinoma of the Breast Masquerading as a Fibroepithelial Lesion on Core Biopsy: A Challenging Case.

IF 3.5 4区医学 Q3 CELL BIOLOGY

Pathobiology Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1159/000540029

Natthawadee Laokulrath, Esther Chuwa, Mihir Gudi, Puay Hoon Tan

引用次数: 0

Abstract

Introduction: Diagnosing low-grade adenosquamous carcinoma (LGASC) presents significant challenges due to its subtle morphology, variable immunohistochemical expression, and resemblance to benign lesions like radial scar and complex sclerosing lesions.

Case presentation: We present a case of a 53-year-old woman with a subareolar mass initially thought to be a fibroepithelial neoplasm on core biopsy. Subsequent wide excision revealed LGASC with oestrogen receptor expression (weak to moderate intensity, 40% of tumour cells).

Conclusion: These findings, rarely reported, highlight the difficulty of diagnosing LGASC on small tissue samples.

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在核心活检中伪装成纤维上皮病变的低级别乳腺腺鳞癌：一个棘手的病例。

导言：由于低级别腺鳞癌（LGASC）形态微妙、免疫组化表达多变，且与放射状瘢痕和复杂硬化性病变等良性病变相似，因此诊断该病面临巨大挑战：我们介绍了一例 53 岁女性的病例，她的乳晕下肿块最初在核心活检中被认为是纤维上皮肿瘤。随后的广泛切除术显示 LGASC 有雌激素受体表达（弱至中等强度，占肿瘤细胞的 40%）：结论：这些罕见的发现凸显了在小组织样本上诊断 LGASC 的难度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathobiology 医学-病理学

CiteScore

8.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Pathobiology'' offers a valuable platform for the publication of high-quality original research into the mechanisms underlying human disease. Aiming to serve as a bridge between basic biomedical research and clinical medicine, the journal welcomes articles from scientific areas such as pathology, oncology, anatomy, virology, internal medicine, surgery, cell and molecular biology, and immunology. Published bimonthly, ''Pathobiology'' features original research papers and reviews on translational research. The journal offers the possibility to publish proceedings of meetings dedicated to one particular topic.