The Comparison of Irisin, Subfatin, and Adropin in Normal-Weight and Obese Polycystic Ovary Syndrome Patients.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Alabbas Abdulkareem Majeed, Alaa Hussein J Al-Qaisi, Waled Abdo Ahmed
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引用次数: 0

Abstract

Background: A combination of genetic and environmental factors contribute to the highly common, complex, and varied endocrine condition known as polycystic ovary syndrome (PCOS) in women. PCOS primarily affects women between the ages of 15 and 35 who are in the early to late stages of pregnancy. Thus, this study aimed to evaluate the serum levels of irisin, subfatin, and adropin in PCOS with and without obesity compared to the control group.

Methods: The present cross-sectional study was conducted in 2022 at Al-Nahrain University/Department of Chemistry (Baghdad, Iraq). The serum levels of irisin, subfatin, and adropin were measured with the enzyme-linked immunosorbent assay (ELISA) method. Body mass index, lipid profile, insulin, fasting glucose, follicle-stimulating hormone, and luteinizing hormone levels were also evaluated. The data were analyzed using one-way analysis of variance (ANOVA) by GraphPad Prism software version 8.0.2. A P<0.05 was considered statistically significant.

Results: The study population comprised PCOS patients (n=90, divided into 45 obese and 45 normal weight) and healthy women (n=30). According to the results, the serum levels of irisin were significantly higher (P<0.001) in obese and normal-weight PCOS patients than controls. While adropin and subfatin were significantly lower in PCOS than controls (P<0.001). Moreover, there are higher levels of serum insulin, fasting glucose, and luteinizing hormone in PCOS women than in healthy women.

Conclusion: According to the findings, PCOS patients had a higher level of irisin than the controls. In addition, decreased subfatin and adropin levels were observed in PCOS patients compared with healthy women. Further research is required to confirm these results in the future.

正常体重和肥胖多囊卵巢综合征患者体内鸢尾素、亚脂肪素和阿托品的比较。
背景:女性多囊卵巢综合征(PCOS)是一种非常常见、复杂多变的内分泌疾病,由遗传和环境因素共同作用所致。多囊卵巢综合征主要影响年龄在 15 至 35 岁之间、处于孕早期至孕晚期的女性。因此,本研究旨在评估与对照组相比,多囊卵巢综合征患者血清中鸢尾素、亚脂肪素和阿托品的水平:本横断面研究于 2022 年在 Al-Nahrain 大学化学系(伊拉克巴格达)进行。采用酶联免疫吸附试验(ELISA)法测定血清中鸢尾素、亚脂肪素和阿托品的水平。此外,还对体重指数、血脂、胰岛素、空腹血糖、卵泡刺激素和黄体生成素水平进行了评估。使用 GraphPad Prism 软件 8.0.2 版对数据进行单因素方差分析(ANOVA)。结果研究对象包括多囊卵巢综合征患者(90 人,其中肥胖 45 人,体重正常 45 人)和健康女性(30 人)。结果显示,血清中鸢尾素的水平明显较高(多囊卵巢综合征):根据研究结果,多囊卵巢综合症患者的鸢尾素水平高于对照组。此外,与健康女性相比,多囊卵巢综合症患者的亚脂肪素和阿托品水平也有所下降。今后还需要进一步的研究来证实这些结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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