Intra-operative Risk Factors Affecting Mortality after Heart Transplantation: A Referral Center Experience in Iran.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Ali Sadeghpour Tabaei, Parham Hashemi
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引用次数: 0

Abstract

Background: Heart transplantation is the preferred treatment for end-stage heart failure. This study investigated the intra-operative risk factors affecting post-transplantation mortality.

Methods: This single-center retrospective cohort study examined 239 heart transplant patients over eight years, from 2011-2019, at the oldest dedicated cardiovascular center, Shahid Rajaee Hospital (Tehran, Iran). The primary evaluated clinical outcomes were rejection, readmission, and mortality one month and one year after transplantation. For data analysis, univariate logistic regression analyses were conducted.

Results: In this study, 107 patients (43.2%) were adults, and 132 patients (56.8%) were children. Notably, reoperation due to bleeding was a significant predictor of one-month mortality in both children (OR=7.47, P=0.006) and adults (OR=172.12, P<0.001). Moreover, the need for defibrillation significantly increased the risk of one-month mortality in both groups (children: OR=38.00, P<0.001; adults: OR=172.12, P<0.001). Interestingly, readmission had a protective effect against one-month mortality in both children (OR=0.02, P<0.001) and adults (OR=0.004, P<0.001). Regarding one-year mortality, the use of extracorporeal membrane oxygenation (ECMO) was associated with a higher risk in both children (OR=7.64, P=0.001) and adults (OR=12.10, P<0.001). For children, reoperation due to postoperative hemorrhage also increased the risk (OR=5.14, P=0.020), while defibrillation was a significant risk factor in both children and adults (children: OR=22.00, P<0.001; adults: OR=172.12, P<0.001). The median post-surgery survival was 22 months for children and 24 months for adults.

Conclusion: There was no correlation between sex and poorer outcomes. Mortality at one month and one year after transplantation was associated with the following risk factors: the use of ECMO, reoperation for bleeding, defibrillation following cross-clamp removal, and Intensive Care Unit (ICU) stay. Readmission, on the other hand, had a weak protective effect.

影响心脏移植术后死亡率的术中风险因素:伊朗转诊中心的经验
背景:心脏移植是治疗终末期心力衰竭的首选方法:心脏移植是治疗终末期心力衰竭的首选方法。本研究调查了影响移植后死亡率的术中风险因素:这项单中心回顾性队列研究对伊朗德黑兰最古老的心血管专科中心沙希德-拉贾伊医院(Shahid Rajaee Hospital,Tehran,Iran)的 239 名心脏移植患者进行了为期八年(2011-2019 年)的研究。主要评估的临床结果是移植后一个月和一年的排斥反应、再入院和死亡率。数据分析采用单变量逻辑回归分析:在这项研究中,107 名患者(43.2%)为成人,132 名患者(56.8%)为儿童。值得注意的是,因出血而再次手术是儿童(OR=7.47,P=0.006)和成人(OR=172.12,PC)一个月死亡率的重要预测因素:性别与较差的预后之间没有相关性。移植后一个月和一年的死亡率与以下风险因素有关:使用 ECMO、因出血再次手术、移除交叉钳后除颤以及重症监护室(ICU)住院。而再次入院则有微弱的保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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