Prognostic Value of the 18F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2024-07-01 DOI:10.1111/coa.14195

Risa Wakisaka, Takumi Kumai, Hiroki Komatsuda, Hidekiyo Yamaki, Michihisa Kono, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Atsutaka Okizaki, Miki Takahara

{"title":"Prognostic Value of the 18F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer","authors":"Risa Wakisaka, Takumi Kumai, Hiroki Komatsuda, Hidekiyo Yamaki, Michihisa Kono, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Atsutaka Okizaki, Miki Takahara","doi":"10.1111/coa.14195","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between <sup>18</sup>F-FDG PET/CT, haematological parameters and prognosis in patients with advanced head and neck cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This was a single-institutional retrospective study of 83 patients with advanced head and neck squamous cell carcinoma (HNSCC) who underwent <sup>18</sup>F-FDG PET/CT imaging before initial treatment between 2014 and 2018. <sup>18</sup>F-FDG PET/CT after treatment was performed in 57 patients. The prognostic parameters of the pre- and post-treatment maximum standardised uptake value (SUV<sub>max</sub>), metabolic tumour volume (MTV), total lesion glycolysis (TLG) of primary tumours and haematological parameters were analysed to evaluate the association between overall survival (OS) and progression-free survival (PFS).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Pre-MTV, pre-TLG and post-SUV<sub>max</sub> were significantly associated with poor OS and PFS (<i>p</i> < 0.05). Haematological parameters, including pretreatment neutrophil/lymphocyte ratio and C-reactive protein/albumin ratio, were associated with <sup>18</sup>F-FDG PET/CT parameters. In multivariate analysis, post-SUV<sub>max</sub> was an independent prognostic factor for OS and PFS.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>A correlation between PET/CT metabolic and haematological parameters was observed. The volume and intensity of <sup>18</sup>F-FDG uptake region, in addition to haematological parameters, are feasible markers for predicting the progression of HNSCC in daily practice. Further, post-SUV<sub>max</sub> could be an independent parameter for predicting poor survival.</p>\n </section>\n </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"49 6","pages":"733-741"},"PeriodicalIF":1.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/coa.14195","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between ¹⁸F-FDG PET/CT, haematological parameters and prognosis in patients with advanced head and neck cancer.

Methods

This was a single-institutional retrospective study of 83 patients with advanced head and neck squamous cell carcinoma (HNSCC) who underwent ¹⁸F-FDG PET/CT imaging before initial treatment between 2014 and 2018. ¹⁸F-FDG PET/CT after treatment was performed in 57 patients. The prognostic parameters of the pre- and post-treatment maximum standardised uptake value (SUV_max), metabolic tumour volume (MTV), total lesion glycolysis (TLG) of primary tumours and haematological parameters were analysed to evaluate the association between overall survival (OS) and progression-free survival (PFS).

Results

Pre-MTV, pre-TLG and post-SUV_max were significantly associated with poor OS and PFS (p < 0.05). Haematological parameters, including pretreatment neutrophil/lymphocyte ratio and C-reactive protein/albumin ratio, were associated with ¹⁸F-FDG PET/CT parameters. In multivariate analysis, post-SUV_max was an independent prognostic factor for OS and PFS.

Conclusion

A correlation between PET/CT metabolic and haematological parameters was observed. The volume and intensity of ¹⁸F-FDG uptake region, in addition to haematological parameters, are feasible markers for predicting the progression of HNSCC in daily practice. Further, post-SUV_max could be an independent parameter for predicting poor survival.

查看原文本刊更多论文

头颈癌中 18F-FDG PET/CT 和血液学参数的预后价值

简介氟18-氟葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）常用于头颈部癌症的分期。本研究旨在评估晚期头颈癌患者的 18F-FDG PET/CT、血液学参数和预后之间的相关性：这是一项单机构回顾性研究，研究对象为2014年至2018年期间在初始治疗前接受18F-FDG PET/CT成像的83例晚期头颈部鳞状细胞癌（HNSCC）患者。57名患者在治疗后进行了18F-FDG PET/CT检查。分析了治疗前和治疗后最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）、原发肿瘤总病变糖酵解（TLG）和血液学参数等预后参数，以评估总生存期（OS）和无进展生存期（PFS）之间的关联：结果：MTV前、TLG前和SUVmax后与OS和PFS差显著相关（p 18F-FDG PET/CT参数）。在多变量分析中，SUVmax后是OS和PFS的独立预后因素：结论：PET/CT代谢和血液学参数之间存在相关性。除血液学参数外，18F-FDG 摄取区的体积和强度也是日常预测 HNSCC 进展的可行指标。此外，SUVmax 后可能是预测不良生存率的一个独立参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.