Cell–drug conjugates

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2024-07-01 DOI:10.1038/s41551-024-01230-6

Yanfang Wang, Jiaqi Shi, Minhang Xin, Anna R. Kahkoska, Jinqiang Wang, Zhen Gu

引用次数: 0

Abstract

By combining living cells with therapeutics, cell–drug conjugates can potentiate the functions of both components, particularly for applications in drug delivery and therapy. The conjugates can be designed to persist in the bloodstream, undergo chemotaxis, evade surveillance by the immune system, proliferate, or maintain or transform their cellular phenotypes. In this Review, we discuss strategies for the design of cell–drug conjugates with specific functions, the techniques for their preparation, and their applications in the treatment of cancers, autoimmune diseases and other pathologies. We also discuss the translational challenges and opportunities of this class of drug-delivery systems and therapeutics. This Review discusses strategies for the design of cell–drug conjugates, the techniques for their preparation, and their translational applications, particularly for the treatment of cancers and autoimmune diseases.

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细胞药物共轭物

通过将活细胞与治疗药物结合，细胞-药物共轭物可以增强两种成分的功能，特别是在药物输送和治疗方面的应用。这些共轭物可被设计成在血液中持久存在、具有趋化性、逃避免疫系统的监控、增殖或保持或改变其细胞表型。在本综述中，我们将讨论具有特定功能的细胞-药物共轭物的设计策略、制备技术及其在治疗癌症、自身免疫性疾病和其他病症中的应用。我们还讨论了这类给药系统和疗法在转化方面的挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.