Unraveling host genetics and microbiome genome crosstalk: a novel therapeutic approach.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-06-27 DOI:10.1016/j.molmed.2024.06.007

Qian Zhang, Dennis Schwarz, Yumei Cheng, Yahya Sohrabi

引用次数: 0

Abstract

The ability of the gut microbiome to adapt to a new environment and utilize a new metabolite or dietary compound by inducing structural variations (SVs) in the genome has an important role in human health. Here, we discuss recent data on host genetic regulation of SV induction and its use as a new therapeutic approach.

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揭示宿主遗传学和微生物组基因组串扰：一种新的治疗方法。

肠道微生物组通过诱导基因组中的结构变异（SV）来适应新环境并利用新的代谢物或膳食化合物的能力对人类健康具有重要作用。在此，我们将讨论有关诱导 SV 的宿主基因调控及其作为一种新的治疗方法的最新数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.