Childhood growth hormone treatment: challenges, opportunities, and considerations

IF 19.9 1区 医学 Q1 PEDIATRICS
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引用次数: 0

Abstract

With long standing demand and popularity, growth hormone treatments continue to be a topic of interest for paediatric endocrinologists and general paediatricians due to ongoing issues regarding their long-term effects, the safety of childhood treatment, and the introduction of long-acting growth hormone preparations in the past decade. Moreover, uncertainty regarding how to approach individual patients and their treatment indications remains, particularly concerning tailored treatment goals and objectives; this uncertainty is further complicated by the multitude of approved indications that surpass substitution therapy. The paediatric endocrinologist thus grapples with pertinent questions, such as what defines reasonable treatment goals for each individual given their indications, and when (and how) to initiate the necessary discussions about risks and benefits with patients and their families. The aim of this Review is to offer advanced physiological concepts of growth hormone function, map out approved paediatric indications for treatment along with evidence on their effects and safety, highlight controversies and complexities surrounding childhood growth hormone treatment, and discuss the potential of long-acting growth hormone and future directions in the realm of childhood growth hormone treatment.

儿童生长激素治疗:挑战、机遇和注意事项。
由于生长激素治疗的长期效果、儿童治疗的安全性以及过去十年中长效生长激素制剂的引入等问题,生长激素治疗一直是儿科内分泌专家和普通儿科医生关注的话题。此外,在如何对待个体患者及其治疗适应症方面仍然存在不确定性,特别是在量身定制的治疗目标和目的方面;而替代疗法之外的众多获批适应症又使这种不确定性变得更加复杂。因此,儿科内分泌医师需要努力解决一些相关问题,如如何根据每个人的适应症确定合理的治疗目标,以及何时(以及如何)与患者及其家属就风险和益处展开必要的讨论。本综述旨在提供有关生长激素功能的先进生理学概念,列出已获批准的儿科治疗适应症及其效果和安全性证据,强调围绕儿童生长激素治疗的争议和复杂性,并讨论长效生长激素的潜力和儿童生长激素治疗领域的未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lancet Child & Adolescent Health
Lancet Child & Adolescent Health Psychology-Developmental and Educational Psychology
CiteScore
40.90
自引率
0.80%
发文量
381
期刊介绍: The Lancet Child & Adolescent Health, an independent journal with a global perspective and strong clinical focus, presents influential original research, authoritative reviews, and insightful opinion pieces to promote the health of children from fetal development through young adulthood. This journal invite submissions that will directly impact clinical practice or child health across the disciplines of general paediatrics, adolescent medicine, or child development, and across all paediatric subspecialties including (but not limited to) allergy and immunology, cardiology, critical care, endocrinology, fetal and neonatal medicine, gastroenterology, haematology, hepatology and nutrition, infectious diseases, neurology, oncology, psychiatry, respiratory medicine, and surgery. Content includes articles, reviews, viewpoints, clinical pictures, comments, and correspondence, along with series and commissions aimed at driving positive change in clinical practice and health policy in child and adolescent health.
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