Lattice radiotherapy in inflammatory breast cancer: report of a first case treated with curative aim.

Radiation oncology journal Pub Date : 2024-06-01 Epub Date: 2024-06-25 DOI:10.3857/roj.2024.00038

Silvana Parisi, Miriam Sciacca, Paola Critelli, Giacomo Ferrantelli, Federico Chillari, Valeria Venuti, Claudio Napoli, Issa Shteiwi, Carmelo Siragusa, Anna Brogna, Antonio Pontoriero, Gianluca Ferini, Anna Santacaterina, Stefano Pergolizzi

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Abstract

Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer characterized by poor prognosis. The treatment requires a multidisciplinary approach, with neoadjuvant chemotherapy, surgery, and radiation therapy (RT). Particularly, high doses of conventional RT have been historically delivered in the adjuvant setting after chemotherapy and mastectomy or as radical treatment in patients ineligible for surgery. Here, we report the case of a 49-year-old woman patient with IBC unsuitable for surgery and treated with a combination of lattice RT and fractionated external beam RT concurrent with trastuzumab, with a curative aim. One year after RT, the patient showed a complete response and tolerable toxicities. This is the first reported case of a not-operable IBC patient treated with this particular kind of RT.

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炎症性乳腺癌的格子放射治疗：首例治愈病例报告。

炎性乳腺癌（IBC）是一种罕见的侵袭性乳腺癌，预后较差。治疗需要采用多学科方法，包括新辅助化疗、手术和放疗（RT）。特别是，大剂量常规 RT 一直以来都是在化疗和乳房切除术后的辅助治疗中使用，或作为不符合手术条件的患者的根治性治疗。在此，我们报告了一例不适合手术的 49 岁 IBC 女性患者的病例，她在接受曲妥珠单抗治疗的同时，接受了格位 RT 和分次体外射束 RT 的联合治疗，以达到治愈目的。RT 治疗一年后，患者出现完全反应，毒性反应可耐受。这是首例报告的无法手术的 IBC 患者接受这种特殊 RT 治疗的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation oncology journal

CiteScore

3.80

自引率

0.00%

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