Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-10-01 DOI:10.1016/j.bpsc.2024.06.009

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引用次数: 0

Abstract

Background

Voice hearing (VH) is a transdiagnostic experience that is common in trauma-related disorders. However, the neural substrates that underlie trauma-related VH remain largely unexplored. While auditory perceptual dysfunction is among the abnormalities implicated in VH in schizophrenia, whether VH in trauma-related disorders also involves auditory perceptual alterations is unknown.

Methods

We investigated auditory cortex (AC)–related functional connectivity (FC) in 65 women with trauma-related disorders stemming from childhood abuse with varying severities of VH. Using a novel, computationally driven and individual-specific method of functionally parcellating the brain, we calculated the FC of 2 distinct AC subregions—Heschl’s gyrus (corresponding to the primary AC) and lateral superior temporal gyrus (in the nonprimary AC)—with both the cerebrum and cerebellum. Then, we measured the association between VH severity and FC using leave-one-out cross-validation in the cerebrum and voxelwise multiple regression analyses in the cerebellum.

Results

We found that VH severity was positively correlated with left lateral superior temporal gyrus–frontoparietal network FC, while it was negatively correlated with FC between the left lateral superior temporal gyrus and both cerebral and cerebellar representations of the default mode network. VH severity was not predicted by FC of the left Heschl’s gyrus or right AC subregions.

Conclusions

Our findings point to altered interactions between auditory perceptual processing and higher-level processes related to self-reference and executive functioning. This is the first study to show alterations in auditory cortical connectivity in trauma-related VH. While VH in trauma-related disorders appears to be mediated by brain networks that are also implicated in VH in schizophrenia, the results suggest a unique mechanism that could distinguish VH in trauma-related disorders.

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听觉皮层在患有创伤相关疾病并听到声音的女性中的功能连接。

背景："听声"（VH）是创伤相关障碍（Trauma-D）中常见的一种跨诊断体验。然而，与创伤相关的听力障碍的神经基础在很大程度上仍未得到研究。虽然听觉知觉功能障碍是精神分裂症VH的异常之一，但创伤D的VH是否也涉及听觉知觉的改变尚不清楚：方法：我们调查了65名患有创伤-D的女性患者的听觉皮层（AC）相关功能连接性（FC），这些女性患者与童年虐待有关，并伴有不同程度的VH。我们使用一种新颖的、计算驱动的、针对个体的大脑功能分区方法，计算了两个不同的听皮层亚区--赫氏回（HG，对应于初级听皮层）和颞上外侧回（lSTG，非初级听皮层）--与大脑和小脑的功能连通性。然后，我们在大脑中使用leave-one-out交叉验证，在小脑中使用体素多元回归分析，测量了VH严重程度与FC之间的关联：结果：我们发现，VH严重程度与左侧lSTG-前顶叶网络FC呈正相关，而与左侧lSTG和默认模式网络的大脑和小脑表征之间的FC呈负相关。VH严重程度不受左侧HG或右侧AC亚区FC的预测：我们的研究结果表明，听觉知觉处理与自我参照和执行功能相关的高层次过程之间的相互作用发生了改变。这是第一项显示与创伤相关的听觉皮层连通性改变的研究。虽然创伤-D 中的 VH 似乎是由也与精神分裂症 VH 有关的大脑网络介导的，但研究结果表明，有一种独特的机制可以区分创伤-D 中的 VH。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.