Biomolecular condensates as drivers of membrane trafficking and remodelling

IF 6 2区 生物学 Q1 CELL BIOLOGY
Rini Ravindran, Stephen W. Michnick
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引用次数: 0

Abstract

Membrane remodelling is essential for the trafficking of macromolecules throughout the cell, a process that regulates various aspects of cellular health and pathology. Recent studies implicate the role of biomolecular condensates in regulating multiple steps of the membrane trafficking pathway including but not limited to the organization of the trafficking machinery, dynamic remodeling of membranes, spatial and functional regulation, and response to cellular signals. The implicated proteins contain key structural elements, most notably prion-like domains within intrinsically disordered regions that are necessary for biomolecular condensate formation at fusion sites in processes like endocytic assembly, autophagy, organelle biosynthesis and synaptic vesicle fusion. Experimental and theoretical advances in the field continue to demonstrate that protein condensates can perform mechanical work, the implications of which can be extrapolated to diverse areas of membrane biology.

作为膜贩运和重塑驱动因素的生物分子凝聚物
膜重塑对于大分子在整个细胞内的贩运至关重要,这一过程调节着细胞健康和病理的各个方面。最近的研究表明,生物分子凝聚物在调节膜贩运途径的多个步骤中发挥作用,包括但不限于贩运机制的组织、膜的动态重塑、空间和功能调节以及对细胞信号的响应。受牵连的蛋白质含有关键的结构元素,最显著的是内在无序区域中的朊病毒样结构域,这些结构域是在内含物组装、自噬、细胞器生物合成和突触囊泡融合等过程中的融合点形成生物分子凝聚物所必需的。该领域的实验和理论进展不断证明,蛋白质凝聚物可以做机械功,其影响可以推广到膜生物学的多个领域。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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