The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.5146/tjpath.2024.13521

Gamze Akbas, Pelin Bagci

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引用次数: 0

Abstract

Objective: Pancreatic stellate cells (PSC) have been defined to be the key players in pancreatic fibrogenesis and carcinogenesis. They undergo myofibroblast-like differentiation, express α-smooth muscle actin (α-SMA), and play a crucial role in injury and inflammation sites. This study aims to evaluate the relationship between α-SMA expression and histopathological parameters of pancreatic ductal adenocarcinoma (PDAC), and investigate their association with prognosis.

Material and methods: Eighty-one consecutive pancreatectomies diagnosed as usual pancreatic ductal adenocarcinoma were included. The stromal density was scored as loose, moderate, or dense, and α-SMA expression was evaluated immunohistochemically.

Results and conclusion: Mean survival was 19.6 months. Male gender, larger tumor diameter ( > 3.7 cm), and older age ( > 64 years) were identified as independent poor prognostic factors. Perineural invasion significantly effected survival. A statistically significant correlation was found between high α-SMA expression and the presence of angioinvasion (p=0.01). Stromal α-SMA expression in PDAC may help determine the risk of angioinvasion.

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胰腺导管腺癌基质和基质 SMA 表达的重要性

目的：胰腺星状细胞（PSC）已被确定为胰腺纤维化和癌变的关键角色。它们会发生肌成纤维细胞样分化，表达α-平滑肌肌动蛋白（α-SMA），并在损伤和炎症部位发挥关键作用。本研究旨在评估α-SMA表达与胰腺导管腺癌（PDAC）组织病理学参数之间的关系，并探讨其与预后的关联：纳入81例诊断为普通胰腺导管腺癌的连续胰腺切除术。基质密度分为疏松、中等或致密，α-SMA的表达通过免疫组化进行评估：结果与结论：平均生存期为 19.6 个月。男性、肿瘤直径较大（> 3.7 厘米）和年龄较大（> 64 岁）是独立的不良预后因素。硬膜外侵犯对生存期有明显影响。α-SMA高表达与血管侵犯之间存在统计学意义上的显著相关性（p=0.01）。PDAC的基质α-SMA表达有助于确定血管侵犯的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.