The Importance of Stroma and Stromal SMA Expression in Pancreatic Ductal Adenocarcinoma.

IF 1.1 Q4 PATHOLOGY

Turkish Journal of Pathology Pub Date : 2024-01-01 DOI:10.5146/tjpath.2024.13521

Gamze Akbas, Pelin Bagci

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引用次数: 0

Abstract

Objective: Pancreatic stellate cells (PSC) have been defined to be the key players in pancreatic fibrogenesis and carcinogenesis. They undergo myofibroblast-like differentiation, express α-smooth muscle actin (α-SMA), and play a crucial role in injury and inflammation sites. This study aims to evaluate the relationship between α-SMA expression and histopathological parameters of pancreatic ductal adenocarcinoma (PDAC), and investigate their association with prognosis.

Material and methods: Eighty-one consecutive pancreatectomies diagnosed as usual pancreatic ductal adenocarcinoma were included. The stromal density was scored as loose, moderate, or dense, and α-SMA expression was evaluated immunohistochemically.

Results and conclusion: Mean survival was 19.6 months. Male gender, larger tumor diameter ( > 3.7 cm), and older age ( > 64 years) were identified as independent poor prognostic factors. Perineural invasion significantly effected survival. A statistically significant correlation was found between high α-SMA expression and the presence of angioinvasion (p=0.01). Stromal α-SMA expression in PDAC may help determine the risk of angioinvasion.

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胰腺导管腺癌基质和基质 SMA 表达的重要性

目的：胰腺星状细胞（PSC）已被确定为胰腺纤维化和癌变的关键角色。它们会发生肌成纤维细胞样分化，表达α-平滑肌肌动蛋白（α-SMA），并在损伤和炎症部位发挥关键作用。本研究旨在评估α-SMA表达与胰腺导管腺癌（PDAC）组织病理学参数之间的关系，并探讨其与预后的关联：纳入81例诊断为普通胰腺导管腺癌的连续胰腺切除术。基质密度分为疏松、中等或致密，α-SMA的表达通过免疫组化进行评估：结果与结论：平均生存期为 19.6 个月。男性、肿瘤直径较大（> 3.7 厘米）和年龄较大（> 64 岁）是独立的不良预后因素。硬膜外侵犯对生存期有明显影响。α-SMA高表达与血管侵犯之间存在统计学意义上的显著相关性（p=0.01）。PDAC的基质α-SMA表达有助于确定血管侵犯的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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