Effect of training on bone quality in rats with insulin resistance induce by fluoride consumption.

Q3 Medicine

Revista de la Facultad de Ciencias Medicas de Cordoba Pub Date : 2024-06-28 DOI:10.31053/1853.0605.v81.n2.42505

Mercedes Lombarte, Brenda Lorena Fina, Victoria Inés García, Maela Lupo, Alfredo Rigalli

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Abstract

When large amounts of Fluoride are consumed produces insulin resistance, but exercise can reverse insulin resistance in rats, because of a high fluoride uptake by bone tissue. However, bone quality has not been studied in those experiments. Therefore, the aim of this work was to evaluate bone quality in rats treated with fluoride when performing exercise. Sprague-Dawley rats were divided into 3 groups (n=6 per group): Control (drinking water without fluoride), Fluoride (drinking water with fluoride 15 mg/L for 30 days) and Exercise (daily running on a treadmill and drinking water with fluoride 15 mg/L for 30 days). Then, bone mineral density, mechanical and histological properties and bone fluoride level were measured. No effect of treatment on any bone parameters were observed. These results indicate that exercise normalizes glucose metabolism in insulin-resistant rats by bone fluoride uptake; however, this increase in bone fluoride does not manifest in bone deterioration.

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训练对服用氟化物导致胰岛素抵抗的大鼠骨骼质量的影响

大量摄入氟会产生胰岛素抵抗，但运动可以逆转大鼠的胰岛素抵抗，因为骨组织对氟的吸收率很高。然而，这些实验并未对骨骼质量进行研究。因此，这项工作的目的是评估氟化大鼠在进行运动时的骨骼质量。Sprague-Dawley 大鼠分为 3 组（每组 6 只）：对照组（饮用不含氟的水）、含氟组（饮用含氟 15 毫克/升的水，为期 30 天）和运动组（每天在跑步机上跑步，饮用含氟 15 毫克/升的水，为期 30 天）。然后，对骨矿物质密度、机械和组织学特性以及骨氟含量进行测量。结果显示，治疗对任何骨骼参数都没有影响。这些结果表明，运动可通过骨氟吸收使胰岛素抵抗大鼠的葡萄糖代谢正常化；然而，骨氟的增加并不会导致骨骼退化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista de la Facultad de Ciencias Medicas de Cordoba Medicine-Medicine (all)

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of the Faculty of Medical Sciences is a scientific publication of the Secretariat of Science and Technology of the Faculty of Medical Sciences of the National University of Cordoba. Its objective is to disseminate and promote research work related to Medical and Biological Sciences. It publishes scientific works of national and international professionals on different topics related to health sciences from the field of medicine, nursing, kinesiology, diagnostic imaging, phonoaudiology, nutrition, public health, chemical sciences, dentistry and related.