Could Triglyceride-Glucose Index, a Predictor of Atherosclerosis, Be Associated with Retinal Vein Occlusion?

Q3 Medicine

Turkish Journal of Ophthalmology Pub Date : 2024-06-28 DOI:10.4274/tjo.galenos.2024.69841

Zeynep Katipoğlu, Meydan Turan

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引用次数: 0

Abstract

Objectives: The triglyceride-glucose (TyG) index is a sign of atherosclerosis in cardiovascular diseases. The TyG index is thought to have clinical significance for the assessment of vascular damage. In this study we aimed to demonstrate the connection between the TyG index and retinal vein occlusion (RVO).

Materials and methods: This case-control observational study involved 492 participants aged 40-90, admitted to the ophthalmology outpatient clinic of our hospital. TyG index was calculated using the formula: ln(fasting TG [mg/dL] × fasting plasma glucose [mg/dL]/2).

Results: The RVO group included 387 patients (181 women and 206 men) and the control group included 115 patients (61 women and 54 men). The average patient age was 62.9±11.1 years in the RVO group and 56.7±8.7 years in the control group. The TyG index was higher in the RVO group (8.9±0.7) than in the control group (8.8±0.6). This difference was statistically significant (p=0.04). The correlation was statistically significant when evaluated according to age and sex by multivariate logistic regression analysis (odds ratio: 1.45, confidence interval: 1.03- 2.02, p=0.03).

Conclusion: The TyG index is a novel atherogenicity index that is derived from routine blood tests and can be used to determine the risk of RVO in at-risk individuals with a simple calculation. Therefore, the TyG index could help as a reliable guide to identify individuals at RVO with high risk and initiate early intervention.

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作为动脉粥样硬化预测指标的甘油三酯-葡萄糖指数是否与视网膜静脉闭塞有关？

目的：甘油三酯-葡萄糖（TyG）指数是心血管疾病中动脉粥样硬化的标志。TyG指数被认为对评估血管损伤具有临床意义。本研究旨在证明 TyG 指数与视网膜静脉闭塞（RVO）之间的联系：这项病例对照观察研究涉及本医院眼科门诊的 492 名 40-90 岁患者。TyG指数的计算公式为：ln（空腹血糖[mg/dL]×空腹血浆葡萄糖[mg/dL]/2）：结果：RVO 组包括 387 名患者（181 名女性和 206 名男性），对照组包括 115 名患者（61 名女性和 54 名男性）。RVO 组患者的平均年龄为（62.9±11.1）岁，对照组患者的平均年龄为（56.7±8.7）岁。RVO 组的 TyG 指数（8.9±0.7）高于对照组（8.8±0.6）。这一差异具有统计学意义（P=0.04）。根据年龄和性别进行多变量逻辑回归分析评估后，相关性具有统计学意义（几率比：1.45，置信区间：1.03- 2.02，P=0.03）：TyG指数是一种新型的致动脉粥样硬化指数，它来源于常规血液检测，只需简单计算即可确定高危人群的RVO风险。因此，TyG 指数可作为识别 RVO 高危人群并启动早期干预的可靠指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Ophthalmology Medicine-Ophthalmology

CiteScore

2.20

自引率

0.00%

发文量

期刊介绍： The Turkish Journal of Ophthalmology (TJO) is the only scientific periodical publication of the Turkish Ophthalmological Association and has been published since January 1929. In its early years, the journal was published in Turkish and French. Although there were temporary interruptions in the publication of the journal due to various challenges, the Turkish Journal of Ophthalmology has been published continually from 1971 to the present. The target audience includes specialists and physicians in training in ophthalmology in all relevant disciplines.