Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy.

IF 3.9 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Pharmaceutical Biology Pub Date : 2024-12-01 Epub Date: 2024-06-30 DOI:10.1080/13880209.2024.2369301
Yuna Zhang, Xianglong Wu, Wenhui Yao, Yadong Ni, Xuansheng Ding
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引用次数: 0

Abstract

Context: Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug for the management of DPN, traditional Chinese medicine (TCM) has increasingly drawn attention of clinicians and researchers around the world due to its characteristics of multiple targets, active components, and exemplary safety.

Objective: To summarize the current status of TCM in the treatment of DPN and provide directions for novel drug development, the clinical effects and potential mechanisms of TCM used in treating DPN were comprehensively reviewed.

Methods: Existing evidence on TCM interventions for DPN was screened from databases such as PubMed, the Cochrane Neuromuscular Disease Group Specialized Register (CENTRAL), and the Chinese National Knowledge Infrastructure Database (CNKI). The focus was on summarizing and analyzing representative preclinical and clinical TCM studies published before 2023.

Results: This review identified the ameliorative effects of about 22 single herbal extracts, more than 30 herbal compound prescriptions, and four Chinese patent medicines on DPN in preclinical and clinical research. The latest advances in the mechanism highlight that TCM exerts its beneficial effects on DPN by inhibiting inflammation, oxidative stress and apoptosis, endoplasmic reticulum stress and improving mitochondrial function.

Conclusions: TCM has shown the power latent capacity in treating DPN. It is proposed that more large-scale and multi-center randomized controlled clinical trials and fundamental experiments should be conducted to further verify these findings.

糖尿病周围神经病变的中医临床前机制和临床研究进展。
背景:糖尿病周围神经病变(DPN)给患者带来了巨大的负担,降低了他们的生活质量。考虑到目前还没有治疗 DPN 的特效药物,传统中药(TCM)因其多靶点、有效成分多、安全性高的特点日益受到世界各地临床医生和研究人员的关注:为了总结中医药治疗 DPN 的现状,为新药开发提供方向,我们对中医药治疗 DPN 的临床效果和潜在机制进行了全面综述:方法:从PubMed、Cochrane神经肌肉疾病组专门登记(CENTRAL)和中国国家知识基础设施数据库(CNKI)等数据库中筛选中医药干预DPN的现有证据。重点是总结和分析 2023 年之前发表的具有代表性的中医临床前和临床研究:本综述确定了临床前和临床研究中约 22 种单味中药提取物、30 多种中药复方和 4 种中成药对 DPN 的改善作用。研究机制的最新进展突出表明,中药通过抑制炎症、氧化应激和细胞凋亡、内质网应激以及改善线粒体功能对 DPN 发挥有益作用:结论:中医药在治疗 DPN 方面显示出强大的潜在能力。建议开展更多大规模、多中心的随机对照临床试验和基础实验,以进一步验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutical Biology
Pharmaceutical Biology 医学-药学
CiteScore
6.70
自引率
2.60%
发文量
191
审稿时长
1 months
期刊介绍: Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.
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