The Asymptomatic Proportion of SARS-CoV-2 Omicron Variant Infections in Households: A Systematic Review

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES
Nancy D. J. Shi, Adrian J. Marcato, Violeta Spirkoska, Niamh Meagher, Juan-Pablo Villanueva-Cabezas, David J. Price
{"title":"The Asymptomatic Proportion of SARS-CoV-2 Omicron Variant Infections in Households: A Systematic Review","authors":"Nancy D. J. Shi,&nbsp;Adrian J. Marcato,&nbsp;Violeta Spirkoska,&nbsp;Niamh Meagher,&nbsp;Juan-Pablo Villanueva-Cabezas,&nbsp;David J. Price","doi":"10.1111/irv.13348","DOIUrl":null,"url":null,"abstract":"<p>Understanding the clinical spectrum of SARS-CoV-2 infection, including the asymptomatic fraction, is important as asymptomatic individuals are still able to infect other individuals and contribute to ongoing transmission. The WHO Unity Household transmission investigation (HHTI) protocol provides a platform for the prospective and systematic collection of high-quality clinical, epidemiological, serological and virological data from SARS-CoV-2 confirmed cases and their household contacts. These data can be used to understand key severity and transmissibility parameters—including the asymptomatic proportion—in relation to local epidemic context and help inform public health response. We aimed to estimate the asymptomatic proportion of SARS-CoV-2 Omicron variant infections in Unity-aligned HHTIs. We conducted a systematic review and meta-analysis in alignment with the PRISMA 2020 guidelines and registered our systematic review on PROSPERO (CRD42022378648). We searched EMBASE, Web of Science, MEDLINE and bioRxiv and medRxiv from 1 November 2021 to 22 August 2023. We identified 8368 records, of which 98 underwent full text review. We identified only three studies for data extraction, with substantial variation in study design and corresponding estimates of the asymptomatic proportion. As a result, we did not generate a pooled estimate or <i>I</i><sup>2</sup> metric. The limited number of quality studies that we identified highlights the need for improved preparedness and response capabilities to facilitate robust HHTI implementation, analysis and reporting, to better inform national, regional and global risk assessments and policymaking.</p>","PeriodicalId":13544,"journal":{"name":"Influenza and Other Respiratory Viruses","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/irv.13348","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Influenza and Other Respiratory Viruses","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/irv.13348","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

Abstract

Understanding the clinical spectrum of SARS-CoV-2 infection, including the asymptomatic fraction, is important as asymptomatic individuals are still able to infect other individuals and contribute to ongoing transmission. The WHO Unity Household transmission investigation (HHTI) protocol provides a platform for the prospective and systematic collection of high-quality clinical, epidemiological, serological and virological data from SARS-CoV-2 confirmed cases and their household contacts. These data can be used to understand key severity and transmissibility parameters—including the asymptomatic proportion—in relation to local epidemic context and help inform public health response. We aimed to estimate the asymptomatic proportion of SARS-CoV-2 Omicron variant infections in Unity-aligned HHTIs. We conducted a systematic review and meta-analysis in alignment with the PRISMA 2020 guidelines and registered our systematic review on PROSPERO (CRD42022378648). We searched EMBASE, Web of Science, MEDLINE and bioRxiv and medRxiv from 1 November 2021 to 22 August 2023. We identified 8368 records, of which 98 underwent full text review. We identified only three studies for data extraction, with substantial variation in study design and corresponding estimates of the asymptomatic proportion. As a result, we did not generate a pooled estimate or I2 metric. The limited number of quality studies that we identified highlights the need for improved preparedness and response capabilities to facilitate robust HHTI implementation, analysis and reporting, to better inform national, regional and global risk assessments and policymaking.

Abstract Image

家庭中无症状的 SARS-CoV-2 Omicron 变体感染者比例:系统回顾。
了解 SARS-CoV-2 感染的临床范围(包括无症状的部分)非常重要,因为无症状的个体仍然能够感染其他人并造成持续传播。世界卫生组织统一住户传播调查(HHTI)方案为前瞻性地系统收集 SARS-CoV-2 确诊病例及其住户接触者的高质量临床、流行病学、血清学和病毒学数据提供了一个平台。这些数据可用于了解与当地疫情相关的关键严重性和传播性参数(包括无症状比例),并为公共卫生应对措施提供依据。我们的目的是估算在统一的高危人群中 SARS-CoV-2 Omicron 变体的无症状感染比例。我们按照 PRISMA 2020 指南进行了系统综述和荟萃分析,并在 PROSPERO 上注册了我们的系统综述(CRD42022378648)。从 2021 年 11 月 1 日至 2023 年 8 月 22 日,我们检索了 EMBASE、Web of Science、MEDLINE、bioRxiv 和 medRxiv。我们发现了 8368 条记录,其中 98 条进行了全文审阅。我们仅确定了三项研究进行数据提取,这些研究的设计和相应的无症状比例估计值存在很大差异。因此,我们没有得出集合估计值或 I2 指标。我们所发现的高质量研究数量有限,这突出表明需要提高准备和响应能力,以促进强有力的 HHTI 实施、分析和报告,从而更好地为国家、地区和全球风险评估和决策提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信