[Research progress on regulatory mechanism of renal copper homeostasis].

Q3 Medicine
生理学报 Pub Date : 2024-06-25
Yu-Qing Liu, Chen Yu
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引用次数: 0

Abstract

Copper is a vital trace metal element necessary for the functioning of living organisms. It serves as a co-factor or structural component in numerous enzymes, participating in crucial biological metabolic processes. Disruptions in copper homeostasis, whether inherited or acquired, such as copper overload, deficiency, or uneven distribution, can contribute to or exacerbate various diseases, including Menkes disease, Wilson's disease, neurodegenerative disorders, anemia, cardiovascular diseases, kidney diseases and cancer. Recent research has highlighted the close correlation between chronic kidney disease and intracellular copper overload. Therefore, renal cells must establish a well-organized and efficient copper regulation network to maintain intracellular copper homeostasis. This review summarizes the processes of copper uptake, intracellular trafficking, storage, and excretion in renal cells, and elucidates the underlying mechanisms involved, aiming to provide a theoretical foundation and potential therapeutic targets for the fundamental investigation and clinical management of kidney-related diseases.

[肾脏铜平衡调控机制的研究进展]。
铜是生物体运作所必需的重要微量金属元素。它是许多酶的辅助因子或结构成分,参与重要的生物代谢过程。无论是遗传性还是获得性铜平衡失调,如铜超载、缺乏或分布不均,都会导致或加剧各种疾病,包括门克氏症、威尔逊氏症、神经退行性疾病、贫血、心血管疾病、肾脏疾病和癌症。最近的研究突出表明,慢性肾病与细胞内铜超载密切相关。因此,肾脏细胞必须建立一个组织良好、高效的铜调节网络,以维持细胞内的铜平衡。本综述总结了肾细胞对铜的摄取、胞内转运、储存和排泄过程,并阐明了其中的内在机制,旨在为肾脏相关疾病的基础研究和临床治疗提供理论依据和潜在的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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