Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics.

IF 5.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Xuewen Deng, Hiroshi Terunuma
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引用次数: 0

Abstract

The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs). Unfortunately, immunosenescence, a progressively dysregulated immunity with age, hampers effective SNC elimination, leading to accumulation, coupled with the release of SASPs, which, in turn, inhibits immunity and heightened susceptibility to aging-associated diseases (AADs). Natural killer (NK) cells, integral to the innate immune system, play a pivotal role in addressing SNCs swiftly. These cells also coordinate with other components of both innate and adaptive immunity to surveil and eliminate these cells. Accordingly, preserving NK cell function during aging is crucial for evading AADs and promoting healthy aging. Alternatively, NK-cell-based therapies present promising avenues for addressing the challenges associated with aging. Notable, recent studies in adoptive NK cell therapy have shown promise in rejuvenating immunosenescence, eliminating SNCs, and alleviating SASPs. This progress provides the proof-concept of adoptive NK cell therapy for senotherapy and holds promise as an emerging revolution in longevity therapeutics.

采用 NK 细胞疗法:长寿疗法的潜在革命性方法。
衰老过程与免疫系统的动态密切相关,在管理衰老细胞(SNCs)及其衰老相关分泌表型(SASPs)方面起着至关重要的作用。不幸的是,随着年龄的增长,免疫衰老--一种逐渐失调的免疫系统--阻碍了 SNC 的有效清除,导致 SNC 的积累和 SASPs 的释放,这反过来又抑制了免疫力,并增加了对衰老相关疾病(AADs)的易感性。自然杀伤(NK)细胞是先天性免疫系统的组成部分,在迅速清除 SNC 方面发挥着关键作用。这些细胞还与先天性免疫和适应性免疫的其他成分协调,以监视和消除这些细胞。因此,在衰老过程中保持 NK 细胞的功能对于避免 AADs 和促进健康衰老至关重要。另外,基于 NK 细胞的疗法也为应对衰老带来的挑战提供了前景广阔的途径。值得注意的是,最近在采用 NK 细胞疗法方面的研究表明,在恢复免疫衰老、消除 SNCs 和缓解 SASPs 方面大有可为。这一进展证明了采用 NK 细胞疗法治疗衰老的概念,并有望成为长寿疗法领域的一场新兴革命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Immunity & Ageing
Immunity & Ageing GERIATRICS & GERONTOLOGY-IMMUNOLOGY
CiteScore
10.20
自引率
3.80%
发文量
55
期刊介绍: Immunity & Ageing is a specialist open access journal that was first published in 2004. The journal focuses on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases with immune etiology, and potential immune interventions to increase health span. All articles published in Immunity & Ageing are indexed in the following databases: Biological Abstracts, BIOSIS, CAS, Citebase, DOAJ, Embase, Google Scholar, Journal Citation Reports/Science Edition, OAIster, PubMed, PubMed Central, Science Citation Index Expanded, SCImago, Scopus, SOCOLAR, and Zetoc.
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