Maternal death by cancer in pregnancy: A descriptive study of the International Network on Cancer, Infertility and Pregnancy

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-06-25 DOI:10.1111/1471-0528.17894

Joosje H. Heimovaara, Evangeline A. Huis in ’t Veld, Christianne A. R. Lok, Alvaro Cabrera Garcia, Michael J. Halaska, Ingrid Boere, Mina Mhallem Gziri, Robert Fruscio, Rebecca C. Painter, Elyce Cardonick, Marry M. van den Heuvel-Eibrink, B. Masturzo, Kristel Van Calsteren, Lia van Zuylen, Frederic Amant, for the International Network on Cancer Infertility and Pregnancy

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引用次数: 0

Abstract

Objective

To characterise pregnant women diagnosed with primary or recurrent cancer who died during pregnancy, during delivery or within 1 year postpartum.

Design

A descriptive study.

Setting

The registry of the International Network on Cancer, Infertility and Pregnancy (INCIP).

Population

Women diagnosed with cancer during pregnancy between 2000 and 2022.

Methods

Using the INCIP registry database, we compared the characteristics of all women with cancer who died during pregnancy, delivery or within 1 year postpartum with those of all women with cancer who survived the first year postpartum.

Main Outcome Measures

Maternal and tumour characteristics and obstetrical and neonatal outcomes.

Results

Of the 2359 women registered in INCIP, there were 131 cases (5.6%) of maternal mortality. Lung cancer (9/14, 64.3% of all registered women with lung cancer), gastro-oesophageal cancer (13/21, 61.9%) and acute leukaemia (17/105, 16.2%) had the highest rates of maternal mortality. Maternal mortality was associated with fewer live births compared with the control group without maternal mortality (99/131, 75.6%, vs 1952/2163, 90.0%; P < 0.001), more elective caesarean sections (64/104, 60.4%, vs 756/1836, 41.2%; P < 0.001) and a lower gestational age at (induced) delivery (34.0 vs 37.1 weeks; P < 0.001), resulting in more preterm births.

Conclusions

Maternal mortality occurred in 5.6% of cancer-in-pregnancy cases and is associated with adverse perinatal outcomes.

查看原文本刊更多论文

孕产妇死于妊娠期癌症：国际癌症、不孕症和妊娠网络的描述性研究。

目的描述确诊为原发性或复发性癌症的孕妇在怀孕期间、分娩时或产后 1 年内死亡的情况：描述性研究：国际癌症、不孕症和妊娠网络（INCIP）登记处：方法：使用 INCIP 登记数据库：利用 INCIP 登记数据库，我们比较了所有在怀孕、分娩期间或产后 1 年内死亡的癌症妇女与所有在产后 1 年内存活的癌症妇女的特征：产妇和肿瘤特征以及产科和新生儿结局：在 INCIP 登记的 2359 名妇女中，有 131 例（5.6%）产妇死亡。肺癌（9/14，占所有登记肺癌妇女的 64.3%）、胃食道癌（13/21，61.9%）和急性白血病（17/105，16.2%）的产妇死亡率最高。与没有孕产妇死亡的对照组相比，孕产妇死亡与活产数减少有关（99/131，75.6%，vs 1952/2163，90.0%；P 结论：与没有孕产妇死亡的对照组相比，孕产妇死亡与活产数减少有关：5.6%的妊娠期癌症病例出现孕产妇死亡，并与不良围产期结果有关。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.