Acquired copy number amplification at the MYC enhancer in human B-precursor acute lymphoblastic leukemia cell lines

IF 4.5 2区医学 Q1 ONCOLOGY

Cancer Science Pub Date : 2024-06-26 DOI:10.1111/cas.16260

Atsushi Watanabe, Lu Wang, Tze King Tan, Kevin Y. Urayama, Toshihiko Kizuki, Chiaki Komatsu, Keiko Kagami, Tamao Shinohara, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Hiroaki Goto, Kazuhito Satou, Tadashi Kaname, Takaomi Sanda, Takeshi Inukai

引用次数: 0

Abstract

Our study highlights the discovery of recurrent copy number alterations in noncoding regions, specifically blood enhancer cluster (BENC-CNA), in B-precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. We demonstrate that BENC-CNA acts as a super-enhancer, driving MYC expression and possibly contributing to the immortalization and proliferative advantage of BCP-ALL cells in vitro.

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人类 B 前体急性淋巴细胞白血病细胞系中 MYC 增强子的获得性拷贝数扩增。

我们的研究强调了在 B 前体急性淋巴细胞白血病（BCP-ALL）细胞系中发现的非编码区（特别是血液增强子簇（BENC-CNA））的重复拷贝数改变。我们证明，BENC-CNA 是一种超级增强子，可驱动 MYC 的表达，并可能促进 BCP-ALL 细胞在体外的永生化和增殖优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Science 医学-肿瘤学

自引率

3.50%

发文量

406

审稿时长

2 months

期刊介绍： Cancer Science (formerly Japanese Journal of Cancer Research) is a monthly publication of the Japanese Cancer Association. First published in 1907, the Journal continues to publish original articles, editorials, and letters to the editor, describing original research in the fields of basic, translational and clinical cancer research. The Journal also accepts reports and case reports. Cancer Science aims to present highly significant and timely findings that have a significant clinical impact on oncologists or that may alter the disease concept of a tumor. The Journal will not publish case reports that describe a rare tumor or condition without new findings to be added to previous reports; combination of different tumors without new suggestive findings for oncological research; remarkable effect of already known treatments without suggestive data to explain the exceptional result. Review articles may also be published.