[Prognostic Significance of Progression of Disease within 24 Months in Mantle Cell Lymphoma].

Abstract

Objective: To investigate the effect of progression of disease within 24 months (POD24) on overall survival (OS) in patients with mantle cell lymphoma (MCL), and compare the clinical characteristics between POD24 and non-POD24 patients.

Methods: A retrospective analysis was performed on 50 MCL patients with treatment indications and regular treatment who were admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to August 2020. According to the occurrence of POD24, the patients were grouped for prognostic evaluation and clinical characteristics comparison.

Results: Univariate Cox regression analysis showed that POD24, PLT, albumin, MIPI score, ECOG PS score, LDH were the factors influencing OS in newly diagnosed MCL patients (all P < 0.05). The results of multivariate Cox regression analysis showed that POD24［HR=16.797(95%CI : 3.671-76.861),P < 0.001］, albumin<40 g/L［HR=3.238(95%CI :1.095-9.572),P =0.034］ and ECOG PS score≥2［HR=4.005(95%CI :1.033-15.521),P =0.045］ were independent risk factors influencing OS in MCL patients. The incidence of PLT<100×10⁹/L (33.3% vs 5.9%, P =0.033) and ECOG PS score ≥2 (45.5% vs 5.9%, P =0.040) were significantly higher in POD24 patients than those in non-POD24 patients.

Conclusion: POD24 is an independent poor prognostic factor affecting the OS of MCL patients, and the patients with PLT<100×10⁹/L and ECOG PS score≥2 at diagnosis have a higher probability of POD24.