Rab GTPases, Active Members in Antigen-Presenting Cells, and T Lymphocytes.

IF 3.6 3区生物学 Q3 CELL BIOLOGY

Traffic Pub Date : 2024-06-01 DOI:10.1111/tra.12950

Nidia Carolina Moreno-Corona, Mercedes Piedad de León-Bautista, Moises León-Juárez, Araceli Hernández-Flores, Juan Carlos Barragán-Gálvez, Orestes López-Ortega

引用次数: 0

Abstract

Processes such as cell migration, phagocytosis, endocytosis, and exocytosis refer to the intense exchange of information between the internal and external environment in the cells, known as vesicular trafficking. In eukaryotic cells, these essential cellular crosstalks are controlled by Rab GTPases proteins through diverse adaptor proteins like SNAREs complex, coat proteins, phospholipids, kinases, phosphatases, molecular motors, actin, or tubulin cytoskeleton, among others, all necessary for appropriate mobilization of vesicles and distribution of molecules. Considering these molecular events, Rab GTPases are critical components in specific biological processes of immune cells, and many reports refer primarily to macrophages; therefore, in this review, we address specific functions in immune cells, concretely in the mechanism by which the GTPase contributes in dendritic cells (DCs) and, T/B lymphocytes.

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Rab GTPases，抗原递呈细胞和 T 淋巴细胞中的活跃成员。

细胞迁移、吞噬、内吞和外吞等过程指的是细胞内外环境之间的密集信息交换，即所谓的囊泡贩运。在真核细胞中，Rab GTPases 蛋白通过 SNAREs 复合体、衣壳蛋白、磷脂、激酶、磷酸酶、分子马达、肌动蛋白或微管蛋白细胞骨架等各种适配蛋白控制这些重要的细胞串联，所有这些都是适当调动囊泡和分布分子所必需的。考虑到这些分子事件，Rab GTPase 是免疫细胞特定生物过程中的关键成分，许多报道主要涉及巨噬细胞；因此，在本综述中，我们将讨论免疫细胞中的特定功能，具体来说，GTPase 在树突状细胞（DC）和 T/B 淋巴细胞中的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Traffic 生物-细胞生物学

CiteScore

8.10

自引率

2.20%

发文量

审稿时长

2 months

期刊介绍： Traffic encourages and facilitates the publication of papers in any field relating to intracellular transport in health and disease. Traffic papers span disciplines such as developmental biology, neuroscience, innate and adaptive immunity, epithelial cell biology, intracellular pathogens and host-pathogen interactions, among others using any eukaryotic model system. Areas of particular interest include protein, nucleic acid and lipid traffic, molecular motors, intracellular pathogens, intracellular proteolysis, nuclear import and export, cytokinesis and the cell cycle, the interface between signaling and trafficking or localization, protein translocation, the cell biology of adaptive an innate immunity, organelle biogenesis, metabolism, cell polarity and organization, and organelle movement. All aspects of the structural, molecular biology, biochemistry, genetics, morphology, intracellular signaling and relationship to hereditary or infectious diseases will be covered. Manuscripts must provide a clear conceptual or mechanistic advance. The editors will reject papers that require major changes, including addition of significant experimental data or other significant revision. Traffic will consider manuscripts of any length, but encourages authors to limit their papers to 16 typeset pages or less.