Boosting endogenous dopamine production: a novel therapeutic approach for Parkinson's disease.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI:10.1016/j.molmed.2024.06.002

Erik H Douma, Marten P Smidt, Lars P van der Heide

引用次数: 0

Abstract

Innovative therapeutic strategies are urgently needed for Parkinson's disease due to limited efficacy of current treatments and a weak therapeutic pipeline. In this forum article, we propose targeting tyrosine hydroxylase phosphorylation as a novel mechanism of action to address this critical need.

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促进内源性多巴胺分泌：治疗帕金森病的新方法。

由于目前的治疗方法疗效有限且治疗渠道薄弱，帕金森病迫切需要创新的治疗策略。在这篇论坛文章中，我们提出以酪氨酸羟化酶磷酸化为靶点，作为一种新的作用机制来满足这一关键需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.