Tumor-associated macrophages: The key player in hepatoblastoma microenvironment and the promising therapeutic target

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Ahmad Adawy, Yoshihiro Komohara, Taizo Hibi
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引用次数: 0

Abstract

The tumor microenvironment of hepatoblastoma (HB), the most common pediatric liver tumor, predominantly exhibits a myeloid immune landscape. in which tumor-associated macrophages (TAMs) are considered the core component. The crosstalk between TAMs and HB cells markedly influences tumor behavior. TAM-derived factors are involved in tumor proliferation and vascular invasion. On the other hand, HB cell secretome attracts, stimulates, and reprograms TAMs to be immunosuppressive in favor of tumor invasion, rather than their innate role in combating tumor growth, such crosstalk sometimes forms bidirectional feedback loops, making the tumor more virulent and resistant to routine therapeutics. Consequently, TAMs are the common denominator of most suggested HB immunotherapeutic strategies. Macrophage immune checkpoint inhibitors, macrophage-mediated antibody-dependent cellular phagocytosis, and the novel chimeric antigen receptor macrophage therapy (CAR Mφ) are currently under trial. In this review, we will summarize the significance of TAMs and their potential role as a therapeutic target in HB.

肿瘤相关巨噬细胞:肝母细胞瘤微环境的关键角色和有希望的治疗靶点
肝母细胞瘤(HB)是最常见的小儿肝脏肿瘤,其肿瘤微环境主要表现为髓系免疫景观,其中肿瘤相关巨噬细胞(TAMs)被认为是核心组成部分。TAMs 和 HB 细胞之间的相互影响明显地影响着肿瘤的行为。TAM 衍生因子参与肿瘤增殖和血管侵袭。另一方面,HB 细胞的分泌物会吸引、刺激和重编程 TAMs,使其具有免疫抑制作用,从而有利于肿瘤的侵袭,而非其对抗肿瘤生长的固有作用,这种串扰有时会形成双向反馈回路,使肿瘤更具毒性,并对常规治疗产生抗药性。因此,TAMs 是大多数建议的 HB 免疫治疗策略的共同点。巨噬细胞免疫检查点抑制剂、巨噬细胞介导的抗体依赖性细胞吞噬作用以及新型嵌合抗原受体巨噬细胞疗法(CAR Mφ)目前正在试验中。在这篇综述中,我们将总结 TAMs 的重要性及其作为 HB 治疗靶点的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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