Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β-Thalassemia

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2024-06-26 DOI:10.1002/jcla.25084

Gizem Zorlu Görgülügil, Ayşegül Uğur Kurtoğlu, Sevcan Uğur, Erdal Kurtoğlu

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引用次数: 0

Abstract

Background/Objectives

CD71⁺ erythroid cells (CECs) are immature red blood cells (proerythroblasts, erythroblasts, and reticulocytes). CECs play an important role in the development of sepsis and cancer by causing immunosuppression. We examined the CEC levels in the peripheral blood of beta thalassemia (βThal) patients and investigated the relationship between CECs and the clinical status of the patients, especially splenectomy.

Methods

Sixty-eight patients with βThal (46 splenectomized and 22 nonsplenectomized) and 15 healthy controls were included in this study. The hemogram parameters, ferritin, and CECs (flow cytometry method) were measured.

Results

It was observed that the CEC level in the patient group was significantly higher than the control group (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy (p < 0.05). CEC levels were higher in patients with nontransfusion-dependent βT (NTD-βThal) than in patients with transfusion-dependent βT (TD-βThal) (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy in both TD-βThal and NTD-βThal groups (p < 0.05). There was a moderate-negative correlation was detected between CECs and Hb levels (r = −0.467; p < 0.05).

Conclusions

High CEC levels in βThal patients develop as a result of ineffective erythropoiesis. We think that keeping CEC levels under control is important for prognosis, especially in patients with splenectomy.

Abstract Image

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CD71+红细胞水平对β-地中海贫血患者预后的重要性

背景/目的：CD71+ 红细胞（CECs）是未成熟红细胞（原红细胞、红细胞和网织红细胞）。CEC 通过引起免疫抑制，在败血症和癌症的发生发展中发挥着重要作用。我们检测了β地中海贫血（βThal）患者外周血中的CEC水平，并研究了CEC与患者临床状况（尤其是脾切除术）之间的关系：本研究共纳入 68 名β地中海贫血患者（46 名脾切除患者和 22 名非脾切除患者）和 15 名健康对照者。研究人员对血液图参数、铁蛋白和 CECs（流式细胞术法）进行了测量：结果显示：患者组的 CEC 水平明显高于对照组（Pβ-Thal患者的高CEC水平是红细胞生成无效的结果。我们认为，控制 CEC 水平对预后非常重要，尤其是对接受脾切除术的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.