Cytotoxic iridoid glycosides from the leaves of Paederia scandens

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI:10.1080/10286020.2024.2358820

引用次数: 0

Abstract

A phytochemical investigation on the 80% EtOH extract of the leaves of Paederia scandens (Lour.) Merr. resulted into the isolation of three undescribed iridoid glycosides, 10-O-trans-p-coumaroyl-(4R,6R)-3,4-dihydro-3α-methylthiopaederoside (1), 10-O-trans-feruloyl-(4S,6R)-3,4-dihydro-2′-O-3α-paederoside (2), and 10-O-trans-caffeoyl-paederosidic acid ethyl ester (3). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, as well as high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against five endocrine tumor cell lines. As a result, compound 1 exhibited some cytotoxicities against all the tested tumor cell lines with IC₅₀ value less than 20.0 μM.

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从Paederia scandens叶子中提取的具有细胞毒性的鸢尾甙。

对 Paederia scandens（Lour.）结果分离出了三种未曾描述过的鸢尾甙，即 10-O-反式对香豆酰-(4R,6R)-3,4-二氢-3α-甲基硫代蛇莓甙 (1)、10-O-反式阿魏酰-(4S,6R)-3,4-二氢-2'-O-3α-蛇莓甙 (2) 和 10-O-反式咖啡酰蛇莓甙酸乙酯 (3)。新化合物的结构是通过一维和二维（1H-1H COSY、HMQC 和 HMBC）核磁共振光谱法以及高分辨质谱法等光谱方法阐明的。分离出的化合物对五种内分泌肿瘤细胞系进行了体外细胞毒性活性测试。结果表明，化合物 1 对所有测试的肿瘤细胞株都具有一定的细胞毒性，其 IC50 值小于 20.0 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.