Associations of systemic immune-inflammation index with high risk for prostate cancer in middle-aged and older US males: A population-based study

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2024-06-24 DOI:10.1002/iid3.1327

Wentao Yao, Jiacheng Wu, Ying Kong, Feng Xu, Yinyi Zhou, Qing Sun, Qingqing Gao, Zhenyu Cai, Chendi Yang, Yuhua Huang

{"title":"Associations of systemic immune-inflammation index with high risk for prostate cancer in middle-aged and older US males: A population-based study","authors":"Wentao Yao, Jiacheng Wu, Ying Kong, Feng Xu, Yinyi Zhou, Qing Sun, Qingqing Gao, Zhenyu Cai, Chendi Yang, Yuhua Huang","doi":"10.1002/iid3.1327","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Systemic immune-inflammation index (SII) provides convincing evaluation of systemic immune and inflammatory condition in human body. Its correlation with prostate cancer (PCa) risk remains uncharted. The principal objective of this investigation was to elucidate the association between SII and the risk for PCa in middle-aged and elderly males.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Analysis entailed multivariate linear and logistic regression, generalized additive model, and smoothing curve fitting using resource from 2007 to 2010 National Health and Nutrition Examination Survey (NHANES). To ascertain robustness and consistency of this association across different demographic strata, we conducted rigorous subgroup analyses and interaction tests.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Among 3359 participants, those with elevated SII displayed higher total prostate-specific antigen (tPSA) levels, higher risk for PCa, and lower free/total PSA (f/t PSA) ratio. Specifically, each unit increase of log<sub>2</sub> (SII) was associated with a 0.22 ng/mL increase in tPSA (β: 0.22, 95% confidence intervals [CI] 0.05–0.38), a 2.22% decline in f/t PSA ratio (β: −2.22, 95% CI −3.20 to −1.23), and a 52% increased odds of being at high risk for PCa (odds ratio [OR]: 1.52, 95% CI 1.13–2.04). People in the top quartile of log<sub>2</sub> (SII) exhibited 0.55 ng/mL increased tPSA (β: 0.55, 95% CI 0.19–0.90), 4.39% reduced f/t PSA ratio (β: −4.39, 95% CI −6.50 to −2.27), and 168% increased odds of being at high risk for PCa (OR: 2.68, 95% CI 1.32–5.46) compared to those in the bottom quartile.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Systemic immune and inflammatory condition, as represented by SII, is independently and positively associated with tPSA levels and the risk for PCa, as well as independently and negatively associated with f/t PSA ratio among middle-aged and older US males. These findings may enhance the effectiveness of PCa screening in predicting positive biopsy results.</p>\n </section>\n </div>","PeriodicalId":13289,"journal":{"name":"Immunity, Inflammation and Disease","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11194977/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunity, Inflammation and Disease","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iid3.1327","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Systemic immune-inflammation index (SII) provides convincing evaluation of systemic immune and inflammatory condition in human body. Its correlation with prostate cancer (PCa) risk remains uncharted. The principal objective of this investigation was to elucidate the association between SII and the risk for PCa in middle-aged and elderly males.

Materials and Methods

Analysis entailed multivariate linear and logistic regression, generalized additive model, and smoothing curve fitting using resource from 2007 to 2010 National Health and Nutrition Examination Survey (NHANES). To ascertain robustness and consistency of this association across different demographic strata, we conducted rigorous subgroup analyses and interaction tests.

Results

Among 3359 participants, those with elevated SII displayed higher total prostate-specific antigen (tPSA) levels, higher risk for PCa, and lower free/total PSA (f/t PSA) ratio. Specifically, each unit increase of log₂ (SII) was associated with a 0.22 ng/mL increase in tPSA (β: 0.22, 95% confidence intervals [CI] 0.05–0.38), a 2.22% decline in f/t PSA ratio (β: −2.22, 95% CI −3.20 to −1.23), and a 52% increased odds of being at high risk for PCa (odds ratio [OR]: 1.52, 95% CI 1.13–2.04). People in the top quartile of log₂ (SII) exhibited 0.55 ng/mL increased tPSA (β: 0.55, 95% CI 0.19–0.90), 4.39% reduced f/t PSA ratio (β: −4.39, 95% CI −6.50 to −2.27), and 168% increased odds of being at high risk for PCa (OR: 2.68, 95% CI 1.32–5.46) compared to those in the bottom quartile.

Conclusion

Systemic immune and inflammatory condition, as represented by SII, is independently and positively associated with tPSA levels and the risk for PCa, as well as independently and negatively associated with f/t PSA ratio among middle-aged and older US males. These findings may enhance the effectiveness of PCa screening in predicting positive biopsy results.

Abstract Image

查看原文本刊更多论文

美国中老年男性全身免疫炎症指数与前列腺癌高风险的关系：一项基于人群的研究。

背景：全身免疫-炎症指数（SII）能令人信服地评估人体的全身免疫和炎症状况。但它与前列腺癌（PCa）风险的相关性仍是一个未知数。本研究的主要目的是阐明 SII 与中老年男性 PCa 风险之间的关系：分析包括多变量线性和逻辑回归、广义加性模型和平滑曲线拟合，使用的资源来自 2007 年至 2010 年的美国国家健康与营养调查（NHANES）。为了确定这种关联在不同人群中的稳健性和一致性，我们进行了严格的亚组分析和交互检验：在 3359 名参与者中，SII 升高者的总前列腺特异性抗原 (tPSA) 水平较高，患 PCa 的风险较高，游离/总 PSA（f/t PSA）比率较低。具体来说，log2（SII）每增加一个单位，tPSA 就会增加 0.22 纳克/毫升（β：0.22，95% 置信区间 [CI]：0.05-0.38），游离/总 PSA 比率下降 2.22%（β：-2.22，95% 置信区间 [CI]：-3.20 至-1.23），患 PCa 的高风险几率增加 52%（比值比 [OR]：1.52，95% 置信区间 [CI]：1.13-2.04）。Log2（SII）最高四分位数的人与最低四分位数的人相比，tPSA增加了0.55纳克/毫升（β：0.55，95% CI 0.19-0.90），f/t PSA比率降低了4.39%（β：-4.39，95% CI -6.50至-2.27），PCa高风险几率增加了168%（比值比[OR]：2.68，95% CI 1.32-5.46）：结论：在美国中老年男性中，以 SII 为代表的全身免疫和炎症状况与 tPSA 水平和 PCa 风险呈独立正相关，与 f/t PSA 比率呈独立负相关。这些发现可能会提高 PCa 筛查在预测阳性活检结果方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology