Diminished levels of insulin-like growth factor-1 may be a risk factor for peripheral neuropathy in type 2 diabetes patients

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-06-24 DOI:10.1111/jdi.14260

Jingyi Zhong, Xiaopu Lin, Xiaobin Zheng, Yanting Zhou, Haishan Huang, Lingling Xu

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Abstract

Aims/Introduction

To investigate risk factors for diabetic peripheral neuropathy (DPN) and to explore the connection between insulin-like growth factor-1 (IGF-1) and DPN in individuals with type 2 diabetes.

Materials and Methods

A total of 790 patients with type 2 diabetes participated in a cross-sectional study, divided into two groups: those with DPN (DPN) and those without DPN (non-DPN). Blood samples were taken to measure IGF-1 levels and other biochemical markers. Participants underwent nerve conduction studies and quantitative sensory testing.

Results

Patients with DPN exhibited significantly lower levels of IGF-1 compared with non-DPN patients (P < 0.001). IGF-1 was positively correlated with the average amplitude of both motor (P < 0.05) and sensory nerves (P < 0.05), but negatively correlated with the vibration perception threshold (P < 0.05). No significant difference was observed between IGF-1 and nerve conduction velocity (P > 0.05), or the temperature detection threshold (P > 0.05). Multivariate regression analysis identified diabetes duration, HbA_1c, and the low levels of IGF-1 as independent risk factors (P < 0.001). Receiver operating characteristic analysis determined that at 8 years duration of diabetes, 8.5% (69.4 mmol/mol) HbA_1c and 120 ng/mL IGF-1, the optimal cut-off points, indicated DPN (P < 0.001).

Conclusions

A reduction of IGF-1 in patients with DPN suggests a potential protective role against axon injury in large fiber nerves of type 2 diabetes patients.

Abstract Image

查看原文本刊更多论文

胰岛素样生长因子-1 水平的降低可能是 2 型糖尿病患者发生周围神经病变的风险因素。

目的/简介：研究2型糖尿病患者发生糖尿病周围神经病变（DPN）的风险因素，并探讨胰岛素样生长因子-1（IGF-1）与DPN之间的联系：共有 790 名 2 型糖尿病患者参加了横断面研究，分为两组：DPN 患者（DPN）和无 DPN 患者（非 DPN）。研究人员采集了血液样本，以测量 IGF-1 水平和其他生化指标。参与者接受了神经传导研究和定量感觉测试：结果：与非 DPN 患者相比，DPN 患者的 IGF-1 水平明显较低（P 0.05），温度检测阈值也明显较低（P > 0.05）。多变量回归分析发现，糖尿病病程、HbA1c 和低水平 IGF-1 是独立的风险因素（P 1c 和 120 纳克/毫升 IGF-1 是最佳临界点，表明存在 DPN（P 结论：DPN 患者的 IGF-1 水平降低，可能与糖尿病病程、HbA1c 和 IGF-1 水平有关：DPN患者体内IGF-1的降低表明，IGF-1对2型糖尿病患者的大纤维神经轴突损伤具有潜在的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).