Successful Deceased Donor Parathyroid Allotransplantation: A Novel Approach in a Patient with Severe Refractory Hypoparathyroidism After Thyroidectomy for Thyroid Cancer.

IF 5.8 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Thyroid Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI:10.1089/thy.2024.0115
Karen Devon, Kathryn Tinckam, Atul Humar, Amin Madani, Jesse D Pasternak, Bianka Saravana-Bawan, Afshan Zahedi
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引用次数: 0
甲状旁腺同种异体移植手术在甲状腺癌甲状腺切除术后严重难治性甲状旁腺功能减退症患者中获得成功:甲状腺癌甲状腺切除术后严重难治性甲状旁腺功能减退症患者的新方法。
背景甲状腺手术后甲状旁腺功能减退是一项重大挑战,尽管采用了常规治疗方法,但仍常常导致患者出现衰弱症状和生活质量下降。我们描述了一名因患低风险甲状腺癌而接受分期甲状腺全切除术的患者的情况,该患者出现了严重的难治性先天性甲状旁腺功能减退症,我们为其成功实施了首例新鲜正常组织死亡供体甲状旁腺移植,受体为免疫缺陷者。方法 我们制定了严格的供体选择和移植方案。供体标准旨在最大限度地降低感染和免疫风险。手术技术包括从已故捐献者身上取回健康的甲状旁腺并移植到受者的肌肉组织中,然后进行免疫抑制。结果 移植后,患者症状迅速缓解,血钙水平恢复正常,并停止了钙剂补充。随访结果表明,移植后患者的功能得以维持,无需额外治疗。结论 死亡供体甲状旁腺同种异体移植是治疗严重难治性甲状旁腺功能减退症的一种很有前景的治疗方法,它强调了甲状腺癌手术并发症的生理性治愈和改善患者生活质量的潜力。为了验证这种创新方法的有效性和安全性,我们有必要开展进一步的研究。
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来源期刊
Thyroid
Thyroid 医学-内分泌学与代谢
CiteScore
12.30
自引率
6.10%
发文量
195
审稿时长
6 months
期刊介绍: This authoritative journal program, including the monthly flagship journal Thyroid, Clinical Thyroidology® (monthly), and VideoEndocrinology™ (quarterly), delivers in-depth coverage on topics from clinical application and primary care, to the latest advances in diagnostic imaging and surgical techniques and technologies, designed to optimize patient care and outcomes. Thyroid is the leading, peer-reviewed resource for original articles, patient-focused reports, and translational research on thyroid cancer and all thyroid related diseases. The Journal delivers the latest findings on topics from primary care to clinical application, and is the exclusive source for the authoritative and updated American Thyroid Association (ATA) Guidelines for Managing Thyroid Disease.
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