Healthcare provider and patient perspectives on the implementation of pharmacogenetic-guided treatment in routine clinical practice.

IF 1.7 3区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Pharmacogenetics and genomics Pub Date : 2024-09-01 Epub Date: 2024-06-18 DOI:10.1097/FPC.0000000000000541
Gurveer Kaur, Chukwunonso K Nwabufo
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引用次数: 0

Abstract

Objective: This study aims to understand patient and healthcare provider perspectives on the integration and application of pharmacogenetics (PGx) testing in routine clinical practice.

Methods: Two anonymous online surveys were distributed globally for healthcare providers and patients respectively on the Qualtrics platform (version 3.24). The surveys were distributed through social platforms, email, and posters with QR codes from 27 October 2023 to 7 March 2024. The surveys evaluated participant familiarity with PGx, previous experience with PGx testing, perceived implementation challenges, and opinions on point-of-care (PoC) PGx testing devices.

Results: This study collected 78 responses from healthcare providers and 98 responses from patients. The results revealed that 64% of healthcare providers had some level of familiarity with PGx, however, PGx testing in clinical practice was low. The primary challenges identified by healthcare providers included limited access to testing and lack of knowledge on PGx test interpretation. In contrast, 52% of patient respondents were aware of PGx testing, with a significant association between awareness and positive opinions toward PGx. Both healthcare providers and patients recognized the value of PoC PGx testing devices, with 98% of healthcare providers and 71% of patients believing PoC devices would improve the accessibility and implementation of PGx testing. Comparative analysis revealed a statistically significant difference in PGx awareness between healthcare providers and patients, with providers being more informed.

Conclusion: Improved PGx awareness, training, clinical guidelines, and PoC PGx testing devices may help promote the implementation of PGx-guided treatments in routine clinical practice.

医护人员和患者对在常规临床实践中实施药物基因指导治疗的看法。
研究目的本研究旨在了解患者和医疗服务提供者对药物遗传学(PGx)检测在常规临床实践中的整合与应用的看法:在 Qualtrics 平台(3.24 版)上向全球医疗服务提供者和患者分别发放了两份匿名在线调查问卷。调查于 2023 年 10 月 27 日至 2024 年 3 月 7 日期间通过社交平台、电子邮件和带有二维码的海报进行发布。调查评估了参与者对 PGx 的熟悉程度、以往的 PGx 检测经验、感知到的实施挑战以及对护理点 (PoC) PGx 检测设备的意见:本研究收集了 78 份医疗服务提供者的回复和 98 份患者的回复。结果显示,64% 的医疗服务提供者对 PGx 有一定程度的了解,但在临床实践中进行 PGx 检测的比例较低。医疗服务提供者面临的主要挑战包括:获得检测的途径有限,以及缺乏 PGx 检测解读方面的知识。与此相反,52% 的受访患者了解 PGx 检验,而了解程度与对 PGx 的积极看法之间存在显著关联。医疗服务提供者和患者都认可 PoC PGx 检验设备的价值,98% 的医疗服务提供者和 71% 的患者认为 PoC 设备将改善 PGx 检验的可及性和实施。比较分析表明,医疗服务提供者和患者对 PGx 的认识在统计学上存在显著差异,医疗服务提供者更了解 PGx:结论:改善 PGx 意识、培训、临床指南和 PoC PGx 检测设备可能有助于促进在常规临床实践中实施 PGx 指导下的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmacogenetics and genomics
Pharmacogenetics and genomics 医学-生物工程与应用微生物
CiteScore
3.20
自引率
3.80%
发文量
47
审稿时长
3 months
期刊介绍: ​​​​Pharmacogenetics and Genomics is devoted to the rapid publication of research papers, brief review articles and short communications on genetic determinants in response to drugs and other chemicals in humans and animals. The Journal brings together papers from the entire spectrum of biomedical research and science, including biochemistry, bioinformatics, clinical pharmacology, clinical pharmacy, epidemiology, genetics, genomics, molecular biology, pharmacology, pharmaceutical sciences, and toxicology. Under a single cover, the Journal provides a forum for all aspects of the genetics and genomics of host response to exogenous chemicals: from the gene to the clinic.
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