Sudden Sensorineural Hearing Loss Before COVID-19, During COVID-19, and After Inactivated Vaccination: Experience From a Tertiary Referral Center in China.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI:10.1097/MAO.0000000000004233

Xin Cao, Haijin Yi

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引用次数: 0

Abstract

Objective: The purpose of this study was to investigate the incidence rate and audiological characteristics of sudden sensorineural hearing loss (SSHL) before the COVID-19 pandemic, during the COVID-19 pandemic, and after inactivated vaccination, and to analyze whether the novel coronavirus or inactivated vaccination have an impact on hearing loss.

Materials and methods: The clinical data of all patients who visited the hospital in July 2019 (before pandemic), July 2020 (during pandemic) and July 2021 (after the inactivated vaccination at least the first basic dose of COVID-19 vaccination) were retrospective analyzed. All patients diagnosed with sudden sensorineural hearing loss in these three periods were screened, and their incidence rate, hearing characteristics, and prognosis were compared.

Results: Overall, the incidence rates of sudden hearing loss in July 2019, July 2020, and July 2021 were 0.59, 0.60, and 0.52% (25 of 4225, 20 of 3322, 28 of 5432), respectively, without significant difference ( χ2 = 0.372, p = 0.830). A significant difference was noted in the incidence of hypertension ( p = 0.02), whereas no significant difference was noted in age ( p = 0.591, p = 0.66), sex ( p = 0.19, p = 0.08), main symptoms ( p = 0.18, p = 0.15), side ( p = 0.483, p = 0.89), audiogram shape ( p = 0.56, p = 0.989), average hearing threshold of affected frequency ( p = 0.81, p = 0.89), average hearing threshold of normal ear affected frequency ( p = 0.65, p = 0.68), average hearing threshold of affected frequency after treatment ( p = 0.49, p = 0.38), days between symptoms onset and hospital visit ( p = 0.62, p = 0.85), treatment plan ( p = 0.551, p = 0.474), and effectiveness ( p = 0.104, p = 0.050).

Conclusion: Our study failed to find a correlation between the novel coronavirus pandemic and inactivated vaccination and SSHL, and there was no direct evidence supporting that COVID-19 or inactivated vaccination had an impact on the incidence rate and prognosis of SSHL patients.

查看原文本刊更多论文

COVID-19 之前、COVID-19 期间和灭活疫苗接种后的突发性感音神经性听力损失：中国一家三级转诊中心的经验。

研究目的本研究旨在调查COVID-19大流行前、COVID-19大流行期间和灭活疫苗接种后突发性感音神经性听力损失（SSHL）的发病率和听力学特征，分析新型冠状病毒或灭活疫苗接种是否对听力损失有影响：回顾性分析2019年7月（流感大流行前）、2020年7月（流感大流行期间）和2021年7月（接种COVID-19灭活疫苗至少第一针基础剂量后）所有来院就诊患者的临床资料。对这三个时间段内所有被诊断为突发性感音神经性听力损失的患者进行筛查，并对其发病率、听力特征和预后进行比较：总体而言，2019 年 7 月、2020 年 7 月和 2021 年 7 月突发性听力损失的发生率分别为 0.59%、0.60% 和 0.52%（4225 人中有 25 人、3322 人中有 20 人、5432 人中有 28 人），无显著差异（χ2 = 0.372，P = 0.830）。高血压发病率有明显差异（p = 0.02），而年龄（p = 0.591，p = 0.66）、性别（p = 0.19，p = 0.08）、主要症状（p = 0.18，p = 0.15）、侧（p = 0.483，p = 0.89）、听力图形状（p = 0.56，p = 0.989）、受影响频率的平均听阈（p = 0.81，p = 0.89）、正常耳受影响频率的平均听阈（p = 0.65，p = 0.68）、治疗后受影响频率的平均听阈（p = 0.49，p = 0.38）、症状出现与到医院就诊之间的天数（p = 0.62，p = 0.85）、治疗方案（p = 0.551，p = 0.474）和疗效（p = 0.104，p = 0.050）：我们的研究未能发现新型冠状病毒大流行和灭活疫苗接种与 SSHL 之间的相关性，也没有直接证据支持 COVID-19 或灭活疫苗接种对 SSHL 患者的发病率和预后有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.